Non-human primate MHC and KIR Allele Discovery and Typing Technology Development

该计划的目标是发现新的NHP MHC I类、MHC II类、杀伤细胞免疫球蛋白样受体(KIR)和Fc受体(FCR)基因、基因座和等位基因；开发NHP研究社区仍可免费访问的基因分型技术；将产生的所有序列提供给NIAID指定的公开可用的数据库。其他重要目标是：i)开发和应用全基因组/全外显子组测序(分别为WGS和WES)到MHC、KIR和FCR区域；以及ii)产生并公开可用的补充信息，包括：a)用于基因/等位基因发现或基因分型的引物和探针定义；以及b)用于基因发现和等位基因频率研究的动物的亲缘关系。这些信息将支持NHP临床前模型中移植和其他研究的开发和解释

The objective of this program is to discover new NHP MHC Class I, MHC Class II, Killer-cell Immunoglobulin like Receptor (KIR), and Fc Receptor (FcR) genes, loci, and alleles; develop genotyping technologies that will remain freely accessible to the NHP research community; provide all sequences generated to the NIAID-designated, publicly available databases. Other important goals are to: i) develop and apply whole genome/whole exome sequencing (WGS, WES respectively) to the MHC, KIR, and FcR regions; and ii) generate and make publicly available supplemental information, including: a) primer and probe definitions used in gene/allele discovery or genotyping; and b) familial relationships of animals used in gene discovery and allele frequency studies. This information will support the development and interpretation of transplantation and other studies in the NHP pre-clinical model