Strategies to Innovate EmeRgENcy Care Clinical Trials Network ("SIREN") - Supplement

项目概要和摘要 这一补充要求支持关键个人的努力，使大学的 匹兹堡网站的战略创新紧急护理临床试验网络（SIREN）， 继续作为招募参与者进入紧急护理研究的中心。 请求提供补充支助，以便在经常供资结束之前维持业务 SIREN的前5年和SIREN的第二个5年的开始。不间断支持 该中心将确保参与者成功入组正在进行的SIREN试验; ICECAP、BOOST-3和Peds-ICECAP。我们会继续支持附属研究， 这些试验：PRECICECAP、Bio-BOOST和electro-BOOST。我们的具体目标仍然是：1。 提供管理结构，以快速实施和招募紧急情况下的临床试验 治疗。2.最大限度地减少多中心临床试验的时间、成本和监管障碍， 紧急设置。3.探索创新战略，以增加识别，招聘， 紧急治疗试验中的知情同意。4.探索创新战略，提高 紧急护理数据，并确保保留在紧急情况下入组的受试者。

Project Summary and Abstract This supplement requests support of effort for key individuals that will allow the University of Pittsburgh site for the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) to continue operations as a Hub for recruiting participants into emergency care research. Supplemental support is requested to maintain operations between the end of regular funding for the first 5 years of SIREN and start of the second 5 years of SIREN. Uninterrupted support of the Hub will ensure successful enrollment of participants into the ongoing SIREN trials; ICECAP, BOOST-3, and Peds-ICECAP. We will continue to support the ancillary studies for these trials: PRECICECAP, Bio-BOOST and electro-BOOST. Our specific Aims remain: 1. Provide administrative structure to rapidly implement and enroll in clinical trials of emergency treatments. 2. Minimize time, cost and regulatory barriers to multicenter clinical trials in emergency settings. 3. Explore innovative strategies to increase identification, recruitment, and consent in emergency treatment trials. 4. Explore innovative strategies to increase quality of emergency care data and to ensure retention of subjects enrolled in emergency settings.