Regulation of Ferroptosis by the p53/CDK/Rb Axis.

项目摘要/摘要： 许多类型的癌症仍然被发现到很晚才能得到有效的治疗。因此，新的系统治疗方法 癌症是必须的。在我们的父应用程序中，我们建议研究称为 铁下垂作为一种潜在的杀死癌细胞的方法。我们的研究集中在理解重要的 调节铁性下垂的细胞途径，以揭示更好的机制，以特异性地靶向癌细胞。 当我们的工作正在进行时，我们大楼的暖通空调系统损坏导致 隔壁的劳务所。因此，该实验室将搬迁到大楼的另一个位置，并将移除一个 我的实验室用来储存样品的超低(-80°C)冰柜。这个冰柜是储存细菌的必需品。 库存、细胞裂解物、蛋白质样本和其他重要试剂。这项管理的目的是 补充是寻求资金购买一台超低80°C的冷冻机，以便我们的研究可以在没有 重大破坏。

Project Summary/Abstract: Many types of cancer are still detected to late to be effectively treated. Therefore, new systemic therapies for cancer are required. In our parent application we proposed to investigate the cell death mechanism called ferroptosis as a potential means to kill cancer cells. Our studies were focused on understanding important cellular pathways that modulate ferroptosis to uncover better mechansism to specifically target cancer cells. While our work was underway, damage to the HVAC system in our building resulted in flooding of a neighboring labortory. As a result, that lab will relocate to another location in the building and will remove an ultralow (-80°C) freezer that my lab was using to store samples. This freezer is essential to store bacterial stocks, cell lysates, protein samples among other important reagents. The purpose of this administrative supplement is to seeks funds to purchase an ultralow -80°C freezer so that our research may continue without major disruption.