Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety (COVID-19 Supplement)

摘要 R21 MH116475题为《杏仁核的功能和神经化学底物--横跨额叶的回路 《发展与焦虑》(FANSDA)旨在研究杏仁核额叶的发育轨迹 (尤其是前扣带回[ACC])正常(N=40)和焦虑(全身性)的回路 焦虑障碍[GAD]，N=40)参与者年龄在16岁到26岁之间。这样做的首要目标是 这项研究旨在揭示一种综合的功能-神经化学生物标记物，用于健康和焦虑的发育。 该奖项最初由伊利诺伊大学芝加哥分校(UIC)的PI于2020年8月12日获得。 随着PI从UIC转移到匹兹堡大学(PITT)，该奖项于4月从UIC转移到匹兹堡大学 8,2021年。该项目在皮特大学成立后，遵循了大学和系关于COVID的指导方针，我们 不得不不时地停止招聘，因为扫描仪站点由于感染了 那根棍子。截至2022年4月，我们已招募18名参与者，17名参与者已接受面试 行为和神经心理测量，8名参与者已经完成了最终的MRI扫描。我们是 我们有信心最终招募80名受试者(每组40名受试者)。我们请求的资金是 具体目的是追回因COVID大流行关闭而支付的工资。这项建议是 回应NOT-MH-21-120 AS 1)它在资助研究的范围内；2)FANSDA在 去年的获奖情况；3)完成招生对当前项目的成功至关重要。

ABSTRACT R21 MH116475 entitled “Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety” (FANSDA) is to examine the developmental trajectories of amygdala-frontal (particularly the anterior cingulate cortex [ACC]) circuitry in healthy (N = 40) and anxious (with generalized anxiety disorder [GAD], N = 40) participants between 16 to 26 years old. The overarching objective of this study is to uncover an integrated functional-neurochemical biomarker for healthy versus anxious development. The award was originally received by the PI at the University of Illinois at Chicago (UIC) on August 12, 2020. As the PI moved from UIC to University of Pittsburgh (Pitt), the award was transferred from UIC to Pitt on April 8, 2021. After the project was set up at Pitt, following the university and department guidelines for COVID, we had to halt recruitment from time to time as the scanner site had to be shut down because of the infection of the staff. As of April 2022, we have recruited 18 participants, 17 participants have been interviewed for behavioral and neuropsychological measures and 8 participants have completed the final MRI scans. We are confident that we will eventually recruit 80 subjects (40 subjects in each group). We request the fund that is specifically aimed to recover salaries paid due to the COVID pandemic shutdown. This proposal is responsive to NOT-MH-21-120 as 1) it is within the scope of the funded research; 2) FANSDA is in the last year of the award; 3) completion of enrollment is critical for the success of the current project.