Center for Skeletal Research (Overall Application)

骨骼研究中心的总体目标是促进跨学科和协作工作， 使我们对骨骼生物学和疾病有了更深入的了解。该中心将在基础上和扩大 马萨诸塞州总医院内分泌科和其他科室的骨科科学家社区， 其他哈佛大学和波士顿大学以及波士顿和更广泛的新英格兰地区的其他机构 区域。这些科学家是多种多样的，包括临床调查人员和实验室调查人员，使用广泛的 来自多个学科的一系列方法。中心将用来实现其目标的机制 包括核心设施、试点和可行性补助计划以及浓缩计划。核心将会 包括管理核心、骨骼表型核心和骨细胞分析核心。这些核心将 强调开发能够推动中心调查人员的科学的新技术，以及 提供专业、高效的服务。这些服务包括组织学、MicroCT成像、人类和 小鼠骨细胞分离，骨的散体和单细胞RNA测序，以及骨信号分析。这个 行政核心将指导研究核心、试点和可行性计划，以及丰富 程序。丰富计划将包括每月一系列的研讨会，由初级调查人员进行演讲 中心、方法研讨会系列、试点和可行性计划、创新奖计划 (旅行奖励和微型赠款计划)，以及年度研讨会/海报会议。飞行员的目标是 可行性资助计划将允许年轻的研究人员开发足够的数据来获得他们自己的数据 在这种情况下，一个强有力的指导计划将补充资金。该系列研讨会将 促进中心科学家之间的合作和交流。年轻的调查人员将展示最新数据 在一些会议上，而另一些会议将从波士顿以外的地方请来杰出的骨骼科学家，以丰富 环境。本系列还将包括Core Director的演示文稿，解释 这些核心将提供一个论坛，供中心调查人员提供反馈，其中将包括对小说的建议 核心服务。行政核心将通过定期安排确保这些活动的有效运作 核心董事会议，每年四次，还将涉及与 中心内的高级调查人员以及来自其他地方具有相关经验的调查人员 领导类似的项目。该中心将致力于与更广泛的社区分享其创新 全国范围内的骨骼科学家。

The overall goal of the Center for Skeletal Research is to foster interdisciplinary and collaborative work that leads to a deeper understanding of skeletal biology and disease. The Center will build upon and expand a community of bone scientists in the Endocrine Unit and other Units at the Massachusetts General Hospital, other Harvard institutions, and Boston University and other institutions in Boston and the broader New England region. These scientists are diverse, including clinical investigators and laboratory investigators using a broad array of approaches from multiple disciplines. The mechanisms that the Center will use to accomplish its goal include Core Facilities, a Pilot and Feasibility Grant Program, and an enrichment program. The Cores will include an Administrative Core, a Skeletal Phenotyping Core and a Bone Cell Analysis Core. These Cores will emphasize the development of new techniques that can drive the science of Center investigators, as well as the provision of expert and efficient service. The services include histology, microCT imaging, human and mouse bone cell isolation, bulk and single cell RNA sequencing of bone, and bone signaling assays. The Administrative Core will direct the research cores, a Pilot and Feasibility Program, and also an enrichment program. The enrichment program will include a monthly seminar series featuring talks by junior investigators of the Center, a methods workshop series, a Pilot and Feasibility Program, an Innovation Awards program (travel awards and mini-grant program), and a yearly Symposium/poster session. The goal of the Pilot and Feasibility Grant Program will be to allow young investigators to develop sufficient data to obtain their own grants; in that context, a vigorous mentoring program will complement the funding. The seminar series will foster collaboration and communication among Center scientists. Young investigators will present current data in some sessions, while others will bring in distinguished bone scientists from outside of Boston to enrich the environment. This series will also include presentations by Core Directors that explain the techniques used in the Cores and will provide a forum for feedback by Center investigators that will include suggestions for novel Core services. An Administrative Core will assure effective functioning of these activities through regular meetings of Core Directors that, four times a year, will also involve meeting with an Advisory Committee made up of senior investigators within the Center, as well as investigators from elsewhere with relevant experience leading similar programs. The Center will be committed to sharing its innovations with the broader community of bone scientists across the country.