Research Projects Core

项目摘要/摘要 普遍定期审议第1阶段和第2阶段CCfN极大地促进了波多黎各研究的进展。一把钥匙 研究人员发起的研究项目：第一阶段和第二阶段子项目，以及第二阶段试点 和协作性种子项目。CCfN总共支持了21个由研究人员发起的研究项目：10 子项目、4个试点项目和7个种子项目。这些项目影响了来自5个机构和8个学术界的科学家 各部门。这些需要丰富多样的神经科学研究主题，实验模型系统， 途径和方法。在科学生产率方面，科布雷资助的绩效指标(子项目、试点和 种子)占CCfN 113篇论文的50%左右，引文量为41%(745篇 总计(1816)。这些调查人员总共获得了约1500万美元的外部资金。子项目占比 已提交的83笔赠款中有52笔(约63%)，48笔资金中有27笔(约56%)。科布雷第二阶段试点和种子项目 占已提交赠款的37.4%，占资助金额约425万美元的43%，占外部资金总额的36.3% 通过这些项目获得的资金。第三阶段CCfN寻求研究人员发起的研究的扩展和发展 成为研究项目核心(RPC)，进一步证明了 CCfN的管理核心、神经成像和电生理设施(Nef)以及研究项目核心。 第三阶段RPC的具体目标是：(1)继续为研究人员发起的研究提供支持 以试点和种子项目的方式开展的项目。RPC将继续支持试点和种子项目， 潜在用户群体和学术机构不断扩大。范围也将扩大到更多 与神经科学相关的研究主题和企业家精神。最重要的是，所有种子项目资金 (5K/种子、25K/年、125K完整赠款周期)和每个试点项目第一年的设备采购 将完全来自机构承诺基金；(2)进一步促进科布雷的发展 通过参与方案活动提高调查人员的生产力和竞争力 由行政部和国家安全局赞助。试验计划参加者须参与 行政核心的能力增强活动和其他适用的初级教育和 培训课程；以及，(3)赞助提交神经可塑性和相关的神经科学研究 向具有竞争力的研究资金来源提供赠款，包括个人、多项PI、计划项目或 来自其他NIH研究所和中心，或其他联邦和非联邦实体的中心赠款。我们的目标是 促进基于研究优势领域的多重PI、计划项目或中心拨款的提交。vt.给出 我们的神经科学家和专业知识的多样性，我们设想他们将合并为下一级的合作研究 场馆。RPC将促进促进研究人员发展的方案目标，加强 竞争力，促进竞争性研究文化的持续发展，成为世界- 公认的自我维持的神经可塑性中心，具有新兴的翻译/治疗应用。

Project Summary/Abstract The UPR Phases 1 and 2 CCfN significantly contributed to advancement of research in Puerto Rico. A key component has been the investigator-initiated research projects: Phase 1 and 2 Subprojects, and Phase 2 Pilot and Collaborative Seed Projects. The CCfN supported a total of 21 investigator-initiated research projects: 10 Subprojects, 4 Pilot, and 7 Seed projects. These projects impacted scientists from 5 institutions and 8 academic departments. These entailed a rich diversity of Neuroscience research themes, experimental model systems, approaches and methodology. In terms of scientific productivity COBRE-funded PIs (Subprojects, Pilots and Seeds) accounted for ~50% of the 113 total publications of the CCfN and contributed to 41% (745) of the citations total (1816). A total of ~$15M in external funds were obtained by these investigators. Subprojects accounted for 52 of the 83 grants submitted (~63%) and 27 of the 48 funded (~56%). COBRE Phase 2 Pilot and Seed projects accounted for 37.4% of grants submitted and 43% of grants funded for ~$4,25M or 36.3% of the total external funds obtained by these projects. Phase 3 CCfN seeks expansion and evolution of investigator-initiated research into a Research Projects Core (RPC) that further evidences the inherent and emerging synergism between the CCfN’s Administrative Core, Neuroimaging and Electrophysiology Facilities (NIEF), and Research Projects Core. Phase 3 RPC specifically aims to: (1) continue providing support for investigator-initiated research projects in the modalities of Pilot and Seed projects. RPC will continue support of Pilots and Seed projects, with an expanded potential user population and academic institutions. Scope will also be expanded to more Neuroscience-related research themes and entrepreneurship. Most importantly, all Seed Projects funds (5K/Seed, 25K/yr, 125K complete grant cycle) and equipment purchases during the first year of each Pilot project will derive entirely from institutional commitment funds; (2) further enhance the development of COBRE investigators’ productivity and competitiveness by their participation in programmatic activities sponsored by the Administrative and NIEF Cores. Pilot Projects participants are required to participate in the capabilities’ enhancement activities of the Administrative CORE and other applicable NIEF education and training sessions; and, (3) sponsor the submission of Neuroplasticity and related neuroscience research grants to competitive sources of research funding, including individual, multiple-PI, program project or center grants from other NIH Institutes and Centers, or other Federal and non-Federal entities. We aim to facilitate submission of multiple-PI, program project, or center grants based on areas of research strength. Given our diversity of neuroscientists and expertise we envision their coalescence into next-level collaborative research venues. The RPC will further the programmatic goals of fostering development of researchers, enhancing competitiveness, promoting continued development of a competitive research culture, and becoming a world- recognized self-sustainable Center for Neuroplasticity with emerging translational/therapeutic applications.