Sensory Mechanisms of Cadmium-Induced Behavioral Disorders Across Generations

项目摘要/摘要 一个需要探索的领域是环境诱发的行为障碍。研究表明，镉(Cd) 毒性可以表现为人类的行为障碍、认知障碍和视力障碍，但 这些不良反应的途径尚不清楚。其漫长的生物半衰期加剧了 了解早期接触Cd如何影响后来的生活结果和子孙后代。家长助学金 有两个目标侧重于从机制上理解镉引起的行为障碍 跨越几代人。 具体目标1：确定镉诱导的视觉行为障碍潜在的神经回路紊乱 使用全脑活动图。 具体目标2：镉引起的行为障碍的代际和代际影响。 这项提议的父母赠款是R00ES030398，用于启动Delia Shelton博士作为独立医生的职业生涯 在迈阿密大学生物系担任助理教授的科学研究员，在那里她 利用她在动物行为、毒理学、神经科学和基因组学方面的科学背景。谢尔顿医生 在了解行为表型和镉毒性方面有丰富的经验 凭借她在研究生学习和K99阶段获得的专业指导技能 使她成为一名成功的独立研究人员和行为毒理学领域的领导者。在……里面 她的新实验室，谢尔顿博士提议测试这一假说，慢性人类饮食相关的CD 暴露会导致晚年和跨代人的视觉行为障碍。在拟议的补编中， 谢尔顿博士将指导多样性补充候选人迈尔斯·卡温顿进行一项研究项目 这补充和扩展了母公司赠款的目标，从而创造了一个独特的机会。焦点 在PA-21-071“促进与健康相关的多样性的研究补充资料”项下提交的这项申请 研究“是为了支持迈尔斯·卡温顿的研究培训和职业发展，通过学习 补硒对镉致视力损害的潜在治疗作用 引导性行为。建议开展研究和职业发展活动，以扩大他们的技能集， 增强他们在毒理学、分子生物学和基因组学方面的知识，并为 专业发展，包括建立网络，在会议上和通过同行传播科学-- 审查出版物，这将增强他们攻读毒理基因组学博士学位的能力。

PROJECT SUMMARY/ABSTRACT An area of needed exploration is environmentally-induced behavioral disorders. Studies show Cadmium (Cd) toxicity can manifest as behavioral disorders, cognitive challenges, and vision deficiencies in humans, but the pathway for these adverse effects is unknown. Its long biological half-life exacerbates the importance of understanding how early-life Cd exposure impacts later life outcomes and future generations. The parent grant has two aims focused on gaining a mechanistic understanding of cadmium-induced behavioral disorders across generations. Specific Aim 1: Identify the disrupted neural circuitry underlying cadmium-induced visuo-behavioral deficits using whole-brain activity mapping. Specific Aim 2: Inter- and transgenerational effects of cadmium-induced behavioral disorders. The parent grant for this proposal is R00ES030398 to launch Dr. Delia Shelton’s career as an independent scientific investigator as an Assistant professor in the Department of Biology at University of Miami, where she draws on her scientific background in animal behavior, toxicology, neuroscience and genomics. Dr. Shelton has extensive experience in understanding behavioral phenotyping and cadmium toxicity which is completed by professional skills in mentoring that she gained in her graduate studies and during the K99 phase of the grant, permitting her to become a successful independent researcher and leader in behavioral toxicology. In her new laboratory, Dr. Shelton proposes to test the hypothesis that chronic human dietary-relevant Cd exposure leads to visuo-behavioral disorders later in life and across generations. In the proposed supplement, Dr. Shelton will mentor the Diversity Supplement candidate, Myles Covington, in pursuing a research project that complements and extends the aims of the parent grant, thereby creating a unique opportunity. The focus of this application submitted under PA-21-071 “Research Supplements to Promote Diversity in Health-Related Research” is to support the research training and career development of Myles Covington through studying the potential therapeutic effects of selenium supplementation for dietary cadmium-induced toxicity on visually- guided behavior. Research and career development activities are proposed to expand their technical skill set, enhance their knowledge in toxicology, molecular biology and genomics, and provide opportunities for professional development including networking disseminating science at conferences and through peer- reviewed publications, which will enhance their ability to pursue a PhD in toxico-genomics.