Examining Factors of Phantom Limb Pain through Person-Centered Assessment

项目摘要 截肢后幻肢痛很常见，但其机制和相关因素尚不清楚。 疼痛仍然不清楚。在不了解相关因素的情况下，临床医生很难推荐 有效的疼痛治疗。这项研究的长期目标是更好地了解影响因素， 在个人层面上的幻肢疼痛，以指导有效的，个性化的治疗方法在未来。 本项目的总体目标是建立生态瞬时的可行性和可接受性， 评估（EMA）的方法来衡量以人为中心的因素，造成幻肢痛。EMA是一个 系统的调查方法，以评估个人的实时个人和环境因素， 自然环境假设EMA调查将达到至少80%的留存率和75%的 截肢人群的反应率。这一假设将通过两个具体目标进行检验。目标1： 调查截肢者中引起幻肢痛的因素。的 实现这一目标的方法将是与截肢者进行焦点小组会议，讨论他们的 幻肢痛的经历和任何加重或缓解因素。来自焦点小组的数据将 用于完善关于幻肢疼痛影响因素的EMA问题列表。目标2：确定 EMA识别幻肢疼痛因素的可行性和可接受性。实现这一目标的方法将 使用重复的EMA调查来测量幻肢疼痛及其影响因素， 在真实的时间和自然环境中进行截肢。将分析EMA问题的答复， 探索导致每位参与者幻肢疼痛的因素。这种做法的可行性和可接受性 将使用招募率、留存率、应答率和半定量法确定该人群中的方法 与参与者进行结构化访谈。这项拟议的研究将通过改进的 了解截肢后幻肢痛的影响因素并建立可行性 以及EMA方法在测量这些因素时的可接受性。预计这些捐款将 显著，因为系统识别患者特异性因素将指导知情的未来治疗 有效的建议，幻肢疼痛的个性化药物，解决关键的公共卫生 需要的这项研究是一个全面的培训计划，其中包括先进的课程，定性 研究和因果发现数据分析，通过研讨会，网络， 研究传播，并指导培训所需的研究技能，以继续申请人的 成为一名独立研究员的道路。明尼苏达大学的广泛研究 基础设施，康复科学的多学科博士课程，以及明尼阿波利斯适应性 设计和工程实验室为完成这项研究和培训创造了理想的环境。

PROJECT SUMMARY Phantom limb pain is common after amputation, but the mechanisms and associated factors contributing to this pain remain unclear. Without an understanding of associated factors, it is difficult for clinicians to recommend effective pain treatments. The long-term goal of this research is to better understand contributing factors to phantom limb pain on an individual level to guide effective, personalized treatment approaches in the future. The overall objective of this project is to establish the feasibility and acceptability of the ecological momentary assessment (EMA) method in measuring person-centered factors contributing to phantom limb pain. EMA is a systematic survey methodology to evaluate real-time personal and environmental factors in an individual’s natural environment. The hypothesis is that EMA surveys will achieve at least 80% retention rate and 75% response rate in the amputation population. This hypothesis will be tested through two specific aims. Aim 1: Investigate factors contributing to phantom limb pain among individuals with amputations. The approach for this aim will be to conduct focus group sessions with individuals with amputations to discuss their experiences with phantom limb pain and any aggravating or relieving factors. Data from the focus groups will be used to refine a list of EMA questions on phantom limb pain contributing factors. Aim 2: Determine the feasibility and acceptability of EMA to identify phantom limb pain factors. The approach for this aim will be to use repeated EMA surveys to measure phantom limb pain and its contributing factors in individuals with amputations in real time and in their natural environment. Responses to EMA questions will be analyzed to explore factors that contribute to phantom limb pain in each participant. The feasibility and acceptability of this method in this population will be determined using recruitment rate, retention rate, response rate, and semi- structured interviews with participants. This proposed research will contribute to science through an improved understanding of contributing factors to phantom limb pain after amputation and the establishment of feasibility and acceptability of the EMA method in measuring these factors. These contributions are expected to be significant because the systematic identification of patient-specific factors will guide informed future treatment recommendations for effective, personalized medicine for phantom limb pain, addressing a critical public health need. This research is part of a comprehensive training plan that includes advanced coursework on qualitative research and causal discovery data analysis, professional development through seminars, networking, and research dissemination, and mentored training in the research skills needed to continue the applicant’s trajectory to becoming an independent researcher. The University of Minnesota’s expansive research infrastructure, the multidisciplinary doctoral program in Rehabilitation Science, and the Minneapolis Adaptive Design and Engineering laboratory create an ideal environment for completing this research and training.