Administrative Core

摘要 行政核心的目的是提供领导和行政管理 拟议的太平洋基因组研究中心(PCGR)旨在利用 夏威夷大学马诺阿分校(UHM)及其集水区的种族/民族多样性进行基因组研究 关于夏威夷和美国存在的疾病风险和结果的种族/民族差异的研究 太平洋。行政核心将建立在若干机构资源的基础上，包括行政资源和 科学性，以促进本U54研究的实施和协调。这一核心也将密切 协调U54资源建设和职业发展活动与UHM实施的活动，以便 在机构层面实现了更高的效率。因此，这一核心服务于主要的行政和综合 用于赠款的函数。U54将依靠一个内部咨询委员会(IAC)，该委员会由主要高级官员组成 科学家进行基因组研究，接受关于研究机会的投入，并促进与 潜在的协同作用的地方倡议。该方案还将受益于社区咨询的投入 由社区领导人和在疾病差异方面有经验的患者权益倡导者组成的委员会(CAB) 和/或生存，以及谁将就我们的活动对社区需求的响应和 期望值。方案评估将在很大程度上依赖于外部咨询委员会(EAB)的投入 在基因组研究领域处于领先地位的外部研究人员。具体目标1将是组织、整合和 提供所有项目和核心的行政管理。具体目标2将是提供项目 管理监督，以跟踪各个项目和核心的里程碑和时间表。具体目标3 将是为了促进合作。行政核心将在支持研究方面发挥重要作用 U54中提出的计划。我们相信，核心联席董事的技能和经验以及经过验证的 本节介绍的方法将提供基础和构建块来实现我们的 目标。

ABSTRACT The purpose of the Administrative Core is to provide the leadership and administrative management for the proposed Pacific Center for Genome Research (PCGR) aimed at capitalizing on the infrastructure at the University of Hawaii at Manoa (UHM) and the racial/ethnic diversity of its catchment area to conduct genomic research addressing the racial/ethnic differences in disease risks and outcomes that exist in Hawai`i and the Pacific. The Administrative Core will build upon a number of institutional resources, both administrative and scientific, to foster the implementation and coordination of the research in this U54. This Core will also closely coordinate the U54 resource-building and career-development activities with those implemented by UHM, so greater efficiency is achieved at the institutional level. Thus, this Core serves major administrative and integrative functions for the grant. The U54 will rely on an Internal Advisory Committee (IAC), consisting of key senior scientists on genome research, to receive input on research opportunities and to facilitate coordination with potentially synergistic local initiatives. The program will also benefit from the input of a Community Advisory Board (CAB) composed of community leaders and patient advocates with experience in disease disparities and/or survivorship, and who will advise on the responsiveness of our activities to community needs and expectations. Program evaluation will heavily rely on the input of an External Advisory Board (EAB) composed of outside investigators who are leaders in genome research. Specific Aim 1 will be to organize, integrate, and provide administrative management of all Projects and Cores. Specific Aim 2 will be to provide project management oversight to track milestones and timelines of the individual Projects and Cores. Specific Aim 3 will be to facilitate collaborations. The Administrative Core will play an essential role in supporting the research program proposed in the U54. We believe that the skills and experience of Core Co-Directors and the proven approaches described in this section will provide both the foundation and the building blocks to achieve our goals.