The effect of self-compassion on integrated treatment outcomes among veterans with co-occurring AUD and PTSD.

项目总结/摘要 与单独的任何一种障碍相比，同时发生的酒精使用障碍（AUD）和创伤后应激障碍 创伤后应激障碍（PTSD）有一个更复杂的临床和治疗过程，对退伍军人造成重大的健康负担。 确定改善AUD/PTSD综合治疗结果的新机制是公共卫生的优先事项 这符合NIAAA的战略目标，即通过改进 行为和药物治疗。自我同情是一种认知技能， 有效的AUD/PTSD综合治疗。自我同情被认为是通过利用一种先天的 护理系统，可以与催产素的亲社会效应，如安全感和信任。的 目前的研究将利用正在进行的NIAAA赞助的临床试验，该试验正在检查催产素的疗效 与安慰剂相比，改善了退伍军人综合行为治疗的结果， AUD/PTSD。这项研究的主要目的是检验两个变量之间的纵向关联， 自我同情和治疗结果。第二个目标是检查退伍军人是否在自我- 同情心和催产素的使用将优于安慰剂条件下的退伍军人。最后，我们将利用 生态瞬时评估（EMA），以捕捉自我同情，酒精， 消费和问题的严重程度，以及现实世界中的PTSD症状。我们假设自我- 同情心将使对AUD和PTSD症状的适应性反应更强（例如，管理渴望，失误， 适应不良的思维模式），从而促进更有效的治疗过程并降低易感性 危险的酒精使用或复发。这是一个重要的和可行的项目，将提供新的见解， 自我同情在患有PTSD的退伍军人中AUD恢复中的作用该项目还将提供 关键的培训经验，以促进候选人的长期目标是一个独立的酒精 研究员根据该奖项的建议，候选人将有机会1）掌握现存的文学 关于AUD/PTSD的行为和药物干预; 2）获得设计和 实施临床试验; 3）磨练自然主义评估方法（如EMA）技能; 4）提高 纵向数据分析能力; 5）通过赠款和手稿提高学术生产力 发展她将通过领导拟议的研究来完成这些精心挑选的培训目标 项目，与高技能的赞助商一起参与全面的导师计划，并参与 精心挑选的教学培训机会计划。培训将在医疗中心进行。 南卡罗来纳州大学成瘾科学部。MUSC是一个著名的学术医学 该中心以其在酒精研究方面的创新和卓越而闻名。因此，候选人将获得一个 研究机构和赞助商具有强大的历史和承诺，临床酒精研究。

PROJECT SUMMARY/ABSTRACT Compared to either disorder alone, co-occurring alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) has a more complex clinical and treatment course that imposes significant health burden on veterans. Identifying novel mechanisms to improve integrated AUD/PTSD treatment outcomes is a public health priority that aligns with NIAAA’s strategic goal to advance treatment of alcohol-related conditions through the refinement of behavioral and pharmacological treatments. Self-compassion is a cognitive skill that may facilitate more effective integrated AUD/PTSD treatment. Self-compassion is proposed to function by tapping into an innate care-giving system that could interact with oxytocin’s prosocial effects such as feelings of safety and trust. The current study will leverage an ongoing NIAAA-sponsored clinical trial that is examining the efficacy of oxytocin compared to placebo to improve outcomes in an integrated behavioral treatment among veterans with AUD/PTSD. The primary goal of the proposed study is to examine the bivariate longitudinal associations between self-compassion and treatment outcomes. The secondary goal is to examine whether veterans higher in self- compassion and administered oxytocin will outperform veterans in the placebo condition. Finally, we will utilize ecological momentary assessment (EMA) to capture the associations between self-compassion, alcohol consumption and problem severity, and PTSD symptoms in a real-world context. We hypothesize that self- compassion will enable more adaptive responding to AUD and PTSD symptoms (e.g., managing craving, lapses, maladaptive thinking patterns) thereby promoting a more efficient treatment course and reducing susceptibility to risky alcohol use or relapse. This is an important and feasible project that will provide novel insights into the role of self-compassion in AUD recovery among veterans with co-occurring PTSD. This project will also provide critical training experiences necessary to facilitate the candidate’s long-term goal to be an independent alcohol researcher. Under the proposed award, the candidate will have the opportunity to 1) master the extant literature on behavioral and pharmacological interventions for AUD/PTSD; 2) acquire new skills in the design and implementation of clinical trials; 3) hone skills in naturalistic assessment methods such as EMA; 4) advance longitudinal data analytic capabilities; and 5) increase scholarly productivity through grant and manuscript development. She will accomplish these deliberately selected training goals by leading the proposed research project, engaging in a comprehensive mentorship plan with highly skilled sponsors, and participating in a carefully selected program of didactic training opportunities. The training will be carried out at the Medical University of South Carolina (MUSC) in the Addiction Sciences Division. MUSC is a renowned academic medical center known for its innovative and excellence in alcohol research. Thus, the candidate will have access to an institution and sponsors with a strong history and commitment to clinical alcohol research.