Establishing Readiness of Dental Professionals in Practice-Based Research and Inter-Professional Care

项目摘要 基于实践的研究(PBR)已经证明了将循证护理整合到临床中的有效性 实践，增强研究结果的概括性，并进行不可能通过 传统的随机对照研究。医学中的PBR网络(PBRN)始于1970年，并已 在推动医学研究成果和将研究证据转化为实践方面发挥了关键作用 设置以提高患者的预后。国家牙科和颅面研究所(NIDCR) 2005年建立了以牙科实践为基础的研究网络，现在被认为是最大的 世界上最大的牙科PBRN。然而，PBR体验还没有成为牙科的一部分 博士后/博士后课程。根据NIDCR的说法，让牙科学生参与研究是至关重要的 活动，并将循证原则纳入牙科课程，以加强他们的批判性思维 评估新知识并将其应用于实践的技能。在本申请中，印第安纳大学(印第安纳大学) 拥有基础科学、PBR、信息学和唾液方面专业知识的牙医学院研究人员 诊断学已经与印第安纳州临床和翻译科学研究所(CTSI)建立了合作关系， 印第安纳大学医学院(IUSM)、普渡药学院、雷根斯特里夫研究所和印第安纳健康 信息交流促进牙科临床教师和实习生的临床研究培训，加强 学生、临床教师和研究人员之间的研究指导伙伴关系。我们将推动知识的发展 唾液和血清生物标记物用于识别易患干燥病(SD)的牙科患者，因此 改善SD高危患者的预后和管理，并通过跨专业人员进行管理 牙科临床医生(DC)、药剂师、风湿病医生和患者之间的沟通和协作。这 应用程序意义重大，因为它寻求1)将下一代DC的知识和技能提升到 进行和领导PBR，2)通过虚拟健康平台促进专业间沟通和护理，以 解决牙科患者的疾病，如SD，需要多学科专业知识才能及时诊断和 管理和3)开发唾液功能减退指数与唾液生物标志物相结合以检测 易患SD的患者，从而改善有SD风险的患者的共同决策和管理。 结果包括DC学生和教职员工完成临床研究和 指导培训和参与拟议的PBR研究，验证用于早期检测的生物标记物 PBR环境中的可持续发展，以及改善与其他医疗保健提供者的协调护理。建议数 研究具有重要意义，因为它为多学科团队诊断和管理奠定了基础 在社区实践环境中受SD影响的个人，并减少目前因以下原因而导致的诊断延误 零散和孤立的牙科医疗服务。

Project Summary Practice-based research (PBR) has demonstrated effectiveness to integrate evidence-based care into clinical practice, enhance the generalizability of research findings and conduct longitudinal studies not possible through traditional randomized controlled studies. The PBR Networks (PBRN) in medicine began in 1970 and have played a crucial role in advancing medical research findings and translating research evidence to practice settings to enhance patient outcomes. The National Institute of Dental and Craniofacial Research (NIDCR) established the Dental Practice-Based Research Network in 2005 and it is now considered to be the largest dental PBRN in the world. However, PBR experiences have yet to become part of the dental predoctoral/postdoctoral curriculum. According to NIDCR, it is essential to ‘engage dental students in research activities and incorporate evidence-based principles into the dental curriculum to enhance their critical thinking skills to evaluate and incorporate new knowledge into practice.’ In this application, the Indiana University (IU) School of Dentistry (IUSD) investigators with expertise in basic science, PBR, informatics, and salivary diagnostics have established collaborations with the Indiana Clinical and Translational Science Institute (CTSI), IU School of Medicine (IUSM), Purdue College of Pharmacy, Regenstrief Institute, Inc. and Indiana Health Information Exchange to advance clinical research training of dental clinical faculty and trainees, and strengthen research mentoring partnership amongst students, clinical faculty and researchers. We will advance knowledge of salivary and serum biomarkers in identifying dental patients susceptible to Sjögren’s Disease (SD), thus improving patient outcomes and management of patients at risk for SD and manage through interprofessional communication and collaboration of dental clinicians (DC), pharmacists, rheumatologists, and patients. This application is significant because it seeks to 1) advance the knowledge and skills of next-generation DCs to conduct and lead PBR, 2) facilitate interprofessional communication and care via virtual health platforms to address dental patients’ conditions such as SD that require multidisciplinary expertise for timely diagnosis and management and 3) develop a salivary hypofunction index in combination with salivary biomarkers to detect patients susceptible to SD thus improving shared decision making and management of patients at risk for SD. The outcomes include measurable increases in DC students and faculty completing clinical research and mentoring training and participation in the proposed PBR study, validation of biomarkers for early detection of SD in PBR settings, and improvement in coordinating care with other health care providers. The proposed research is significant because it lays the foundation for multidisciplinary teams to diagnose and manage individuals affected with SD in community practice settings and reduce current delays in diagnosis due to fragmented and siloed dental-medical care.