NCI SBIR Contract Topic 428 Phase II (Solicitation Number: BAA 75N91022R00027): Cloud-based Liquid-biopsy and Radiomics Platform for the Cancer Research Data Commons

多组学数据集的综合分析正在彻底改变癌症研究和患者护理。为了充分利用CRDC的PB级数据，EarlyDx将其液体活检云计算平台与CRDC数据存储库无缝集成。液体活检提供了一种非侵入性的方法来询问肿瘤的基因组和表观基因组谱。将CRDC数据集与用户提供的采血管数据进行联合分析，将确保CRDC得到广泛的用户采用。为此，在第一阶段，EarlyDx开发了一个原型，通过DCF将其信息学工具与CRDC多组学数据集成功集成。第二阶段项目的目标是完成第一阶段的原型，并扩展原型，将成像数据集成到CRDC中，并实施深度学习工具，以进行综合多组学和放射组学分析。具体而言，我们将实现以下目标：1）完成多组学分析的I期原型; 2）扩展CRDC成像数据分析平台; 3）实现综合分析工具; 4）实现诊断工具; 5）招募至少100名用户进行可用性测试。我们与CRDC集成的平台将加速癌症研究，并促进临床应用，如广泛人群的癌症检测和治疗。

Integrative analysis of multi-omics datasets is revolutionizing cancer research and patient care. To take advantage of the full breadth of CRDC’s petabyte-scale data, EarlyDx will seamlessly integrate its liquid biopsy cloud-computing platform with CRDC data repositories. Liquid biopsies provide a non-invasive approach for interrogating the genomic and epigenomic profiles of tumors. Co-analysis of CRDC datasets with userprovided data from a tube of blood will ensure broad user adoption of the CRDC. To that end, in Phase I, EarlyDx has developed a prototype that successfully integrates its informatics tools with the CRDC multi-omics datasets through the DCF. The goal of this Phase II project is to finalize the Phase I prototype and expand the prototype to integrate imaging data in the CRDC and implement deep learning tools for integrative multi-omics and radiomics analysis. Specifically, we will conduct the following aims: 1) finalize the Phase I prototype for multi-omics analysis; 2) expand the platform for CRDC imaging data analysis; 3) implement integrative analysis tools; 4) implement diagnostic tools; 5) recruit at least 100 users for usability testing. Our platform with CRDC integration will accelerate cancer research and promote clinical applications such as cancer detection and treatment in broad populations.