Spatial repellents to reduce the outdoor transmission of malaria

摘要 尽管人们认识到迫切需要采取公共卫生干预措施， 传播，没有这种经过验证的干预措施。经四氟菊酯处理的粗麻布条（TTHFS） 提供承诺，显示在坦桑尼亚设置超过六个月的蚊子叮咬威慑。这个项目 旨在通过对坦桑尼亚研究的荟萃分析，半 在泰国和柬埔寨进行实地和实地测试，并在柬埔寨进行用户可接受性研究，为今后的研究提供信息。 研究和干预设计。 目的1：确定TTHFs特征与其保护效果之间的关系， 坦桑尼亚时间我假设最佳的四氟苯菊酯浓度，织物条的大小，和温度 从坦桑尼亚先前的研究中可以确定TTHFs的范围，并且高剂量对疗效的影响 温度和相对湿度可以量化。 目的2：研究TTHFS在泰国和柬埔寨户外随时间推移的保护效果 条件我假设，在坦桑尼亚有效的TTHFs将在一个国家显示类似的疗效水平。 针对泰国和柬埔寨疟疾病媒的环境非常不同，温度和 湿度对药效持续时间的影响。 目标3：确定用户的可接受性，并确定TTHFs采用的可修改障碍， 柬埔寨护林员和森林游客。我假设柬埔寨的护林员和森林游客 会觉得TTHFs可以接受，因为他们能够减少蚊子叮咬，但会感到不舒服， 由于他们在TTHFS方面的经验有限，他们对产品的尺寸、形状和设计有偏好， TTHFS。 这项研究将为未来在东南亚进行的优化TTHFs的干预性研究提供信息， 在K01研究之后。

ABSTRACT Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthrin-treated hessian fabric strips (TTHFS) offer promise, showing more than six months of mosquito bite deterrence in Tanzanian settings. This project seeks to clarify and advance the evidence base on TTHFS through meta-analysis of Tanzanian studies, semi- field and field testing in Thailand and Cambodia, and user acceptability studies in Cambodia to inform future studies and intervention designs. Aim 1: To determine the relationship between TTHFS characteristics and their protective efficacy over time in Tanzania. I hypothesize that an optimal transfluthrin concentration, fabric strip size, and temperature range for TTHFS can be identified from prior studies in Tanzania, and that impacts on efficacy caused by high temperature and relative humidity can be quantified. Aim 2: To investigate the protective efficacy of TTHFS over time in Thai and Cambodian outdoor conditions. I hypothesize that TTHFS that are efficacious in Tanzania will show similar levels of efficacy in a very different setting against Thai and Cambodian malaria vectors, with similar effects of temperature and humidity on the duration of efficacy. Aim 3: To establish user acceptability and identify modifiable barriers to TTHFS uptake among Cambodian forest rangers and forest goers. I hypothesize that Cambodian forest rangers and forest goers will find TTHFS acceptable due to their ability to reduce mosquito bites, but will be uncomfortable with the product given their limited experience with TTHFS and will have preferences on the size, shape, and design of TTHFS. This study will inform a future interventional study of an optimized TTHFS in Southeast Asia, to be performed subsequent to this K01 study.