Core Research Services for Molecular Imaging and Imaging Sciences

核心设施支持成像科学中的翻译研究。放射学和影像科学多年来一直在发展。主要目标是用核心设施支持影像研究，并培训学术放射科医生和内科影像科学家。放射诊断研究实验室已发展成为一个更广泛的计划，为放射学和影像科学相关的转化研究提供核心支持，维护放射学核心基础科学的基础设施，包括生物学、分子生物学机舱、合成化学机舱、体内和体外显微镜、BSL 2组织培养室、冷藏室、共聚焦显微镜、体内显微镜、造影剂开发、干细胞运输、细胞迁移、纳米颗粒分析和表征、整合素拮抗剂合成化学、多模探针、动脉粥样硬化探针、结肠息肉的分子成像、多模成像、分子干预和脂体化学。该核心设施现在还运行着微正电子发射断层扫描(PET)和微型计算机断层扫描(CT)系统，用于进行PET/CT评估啮齿动物模型的结构和代谢变化。科学家们还可以使用7T磁共振显微成像仪和3T临床磁共振扫描仪。该部门有各种共享的设备和设施，支持放射学和影像科学调查人员和协作的内部调查人员和实验室，以及初级临床、翻译和基础科学调查人员的培训。

The core facilities support translational research in the imaging sciences. Radiology and Imaging Sciences has evolved over the years. Supporting imaging research with core facilities and training academic radiologists and imaging scientists in the Intramural Program is the main goal. The Laboratory for Diagnostic Radiology Research has evolved into a more broad program for core support of translational research related to Radiology and Imaging Sciences, maintaining infrastructure for core basic science radioactive and non-radioactive lab facilities in Radiology with biology, molecular biology bays, synthetic chemistry bays, in vivo and ex vivo microscopy, BSL 2 tissue culture rooms, cold rooms, confocal microscopy, in vivo microscopy, contrast agent development, stem cell trafficking, cell migration, nanoparticle analysis and characterization, integrin antagonist synthetic chemistry, multi-modality probes, atherosclerosis probes, molecular imaging of colonic polyps, multi-modality imaging, molecular interventions, and liposomal chemistry. The core facility also now operates a micro-positron emission tomography (PET) and micro-computerized tomography (CT) system for performing PET/CT evaluating structural and metabolic changes in rodent models. There is also a 7T MRI Microimager and 3T clinical MRI scanner available to the scientists. There is a variety of shared equipment and facilities in the department that supports Radiology and Imaging Sciences Investigators and collaborative Intramural Investigators and labs, as well as the training of junior clinical, translational and basic science investigators.