The effectiveness of Botulinum toxin on persistent pelvic pain in women with endometriosis

与子宫内膜异位症相关的慢性盆腔疼痛知之甚少。一些患有慢性骨盆疼痛的女性骨盆肌肉痉挛。在患有子宫内膜异位症和其他类型慢性盆腔疼痛的女性中，肌肉痉挛可能是疼痛的重要组成部分。肉毒杆菌毒素注射被广泛用于治疗与肌肉过度活动和痉挛有关的疾病。将肉毒杆菌毒素注射到患有骨盆疼痛的女性的盆腔肌肉中的研究表明，肉毒杆菌毒素可以减轻疼痛和痉挛，但很少有女性被研究过，以得出其有效性。我们希望证明，肉毒杆菌毒素注射治疗女性盆腔疼痛将缓解她们的部分盆腔疼痛。 符合条件的受试者是有慢性盆腔疼痛和子宫内膜异位症病史的健康女性。受试者被随机分为肉毒杆菌毒素注射组和安慰剂(盐水)注射组。一个月后，我们评估疼痛的存在，并为所有女性提供肉毒杆菌毒素注射。我们还评估了重新注射的必要性。 本研究的目的是确定盆底肌肉注射肉毒杆菌毒素是否可以缓解患有骨盆肌肉痉挛的女性的慢性盆腔疼痛。我们于2019年7月完成了这项研究，所有30名受试者都完成了这项研究；数据分析正在进行中。

Chronic pelvic pain associated with endometriosis is poorly understood. Some women with chronic pelvic pain have muscle spasm of their pelvic muscles. Muscle spasm may be a significant part of pain in women with endometriosis and other types of chronic pelvic pain. Botulinum toxin injection is widely used to treat conditions associated with excessive muscle activity and spasm. Studies of botulinum toxin injected into pelvic muscles of women with pelvic pain have shown a decrease pain and spasm, but too few women have been studied to conclude its effectiveness. We expect to show that botulinum toxin injection in women with pelvic pain will relieve some of their pelvic pain. Eligible subjects were otherwise healthy women with chronic pelvic pain and a history of endometriosis. Subjects were randomized to either botulinum toxin injection or placebo (salt water) injection. After one month, we evaluated the presence of the pain and all women were offered botulinum toxin injection. We also evaluated the need for reinjection. The purpose of this study is to determine if botulinum toxin injections into the muscles of the pelvic floor can relieve chronic pelvic pain in women with pelvic muscle spasm. We completed the study in July 2019 with all 30 subjects completing the study; data analysis is ongoing.