Advancing communication strategies to support future HIV vaccine use among African Americans in the South.

摘要 在我们进入艾滋病毒大流行的第五个十年之际，艾滋病毒疫苗研究和开发方面的创新 使我们比以往任何时候都更接近于获得可以终止艾滋病毒感染的有效疫苗。不幸的是， 疫苗犹豫（即，尽管有疫苗接种服务，但仍延迟接受或拒绝接种疫苗） 对未来接受已被证实的疫苗构成了重大威胁。在全球范围内，非洲人后裔一直受到 艾滋病毒大流行病给这些国家造成了不成比例的负担，它们面临着更高的发病率和死亡率。在美国， 种族主义、对卫生保健的不信任、社区参与不足和对卫生保健的关注 关于疫苗知识的缺乏可能会加剧疫苗犹豫，减少这一人群未来的接种。到 为了准备一种不可避免的艾滋病毒疫苗，包括那些部分有效的疫苗，我们需要进行有针对性的实地测试， 具有说服力的信息宣传活动，反对疫苗相关的神话和错误信息，来自 值得信赖的来源，并具有文化相关性和影响力。此外，活动必须利用数字平台 大部分人口向其寻求重要的健康信息。以能力为导向 机会动机-行为与少数民族健康及健康差异研究框架，本研究 将利用正在进行的艾滋病毒疫苗的参与性研究方法、人工智能和基础设施 杜克大学的一项研究：1）确定对艾滋病毒疫苗属性和传播的偏好 在北卡罗来纳州使用离散选择实验的非裔美国人的策略; 2）开发和试点 众包和深度学习干预措施，以评估可接受性、可行性和对艾滋病毒的初步影响 疫苗知识、信心和意愿; 3）评估众包与深度学习的影响 计算机动画干预对艾滋病毒疫苗知识、信心和接种意愿的影响， 使用三臂随机实验的对照臂。本研究的结果将：a）使我们能够比较 与社区驱动、社区参与和专家驱动的干预措施相关的成果， 对艾滋病毒疫苗的有利态度; B）为非洲人确定有效的艾滋病毒疫苗宣传信息 美国人; c）告知指导方针，告知未来新型疫苗的推出和推广。

Abstract As we enter the fifth decade of the HIV pandemic, innovations in HIV vaccine research and development have moved us closer than ever to the availability of effective vaccines that could end HIV acquisition. Unfortunately, vaccine hesitancy (i.e., delay in acceptance or refusal of vaccination despite availability of vaccination services) poses a major threat to the future uptake of a proven vaccine. Globally, people of African descent have been disproportionately burdened by the HIV pandemic, facing higher morbidity and mortality. In the United States, the convergence of racism, mistrust in the healthcaresystem, inadequate community engagement,and concerns regarding vaccine literacy may exacerbate vaccine hesitancy, reducing future uptake within this population. To prepare for an inevitable HIV vaccine, including those with partial efficacy, we need to field-test targeted messaging campaigns that: are persuasive, counter vaccine-related myths and misinformation, come from trusted sources, and are culturally relevant and impactful. Moreover, campaigns must leverage digital platforms to which greater proportions of the population turn for critical health information. Guided by the Capability Opportunity Motivation—Behavior and Minority Health and Health Disparities Research Frameworks, this study will leverage participatory research methods, artificial intelligence, and infrastructure from ongoing HIV vaccine research at Duke University to: 1) Identify preferences regarding HIV vaccine attributes and communication strategies for African Americans in North Carolina using discrete choice experiments; 2) Develop and pilot crowdsourced and deep learning interventions to assess acceptability, feasibility, and preliminary impact on HIV vaccine literacy, confidence, and willingness; and 3) Evaluate the impact of a crowdsourced vs. a deep learning computer animation intervention on HIV vaccine literacy, confidence, and willingness to vaccinate compared to a control arm using a three-arm randomized experiment. The results of this study will: a) enable us to compare outcomes associated with community-driven, community-engaged, and expert-driven interventions to promote favorable attitudes towards an HIV vaccine; b) identify effective HIV vaccine promotion messages for African Americans; c) inform guidelines informing the rollout and promotion of future novel vaccines.