Novel prolonged-release polymeric microparticles for relief of intractable cancer-related pain

对于10-30%的晚期癌症患者，尽管通过口服或注射给予大剂量吗啡样药物，但仍会出现顽固性疼痛，因此可能需要更具侵入性的给药途径。该项目将利用创新的聚合物化学来开发生物可侵蚀的延长释放聚合物微粒，以将止痛药递送到靠近介导其作用的细胞的脊髓液中，以期在这些患者中产生延长的镇痛时间。

For the 10-30% of patients with advanced cancer who experience intractable pain despite administration of large doses of morphine-like drugs by mouth or injection, more invasive dosing routes may be needed. This project will utilise innovative polymer chemistry to develop bioerodable prolonged-release polymer microparticles to deliver pain-killers into the spinal fluid near to the cells that mediate their actions, with a view to producing prolonged periods of analgesia in these patients.