Novel prolonged-release polymeric microparticles for relief of intractable cancer-related pain

新型缓释聚合物微粒可缓解顽固性癌症相关疼痛

• 批准号: nhmrc : 1107723
• 负责人: Prof Andrew Whittaker
• 金额: $ 54.51万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-prolonged-release-related-pain/662997
• 关键词: Novel; prolonged; release; polymeric; microparticles

For the 10-30% of patients with advanced cancer who experience intractable pain despite administration of large doses of morphine-like drugs by mouth or injection, more invasive dosing routes may be needed. This project will utilise innovative polymer chemistry to develop bioerodable prolonged-release polymer microparticles to deliver pain-killers into the spinal fluid near to the cells that mediate their actions, with a view to producing prolonged periods of analgesia in these patients.

对于10-30%的晚期癌症患者，尽管通过口服或注射给予大剂量吗啡样药物，但仍会出现顽固性疼痛，因此可能需要更具侵入性的给药途径。该项目将利用创新的聚合物化学来开发生物可侵蚀的延长释放聚合物微粒，以将止痛药递送到靠近介导其作用的细胞的脊髓液中，以期在这些患者中产生延长的镇痛时间。