CTSA K12 Program at The Scripps Research Institute

项目摘要/摘要 斯克里普斯翻译研究所(SRTI)的K12计划旨在提供和开发全面的翻译 科学能力和成功的翻译科学家特征，推动毕业生进入调查 在学术机构、研究机构、生物技术公司、社区和公共卫生部门工作 计划，以及确定优先事项的政府机构。在斯克里普斯研究公司内部，最大的私人、非营利性生物医学 美国的研究组织，并与合作伙伴斯克里普斯健康，雷迪儿童基因组研究所 医学院和圣地亚哥州立大学(SDSU)，我们将为早期职业生涯提供一个独特的、鼓舞人心的环境 生物医学研究人员将我们的翻译科学方法论应用于切割的设计和实施- EDGE翻译研究。6名K12学者，级别从临床研究员到初级教员，在5年内接受培训 完成后，将支持2-4年的指导职业发展，为每个人量身定做，以发现 研究利基，并产生个人拨款提交和研究独立性的初步结果。 我们将强调由跨学科顾问团队指导的研究活动，并辅以学术核心和试验 支持提供赠款管理、可行性评估、监管支持、社区参与咨询、 研究导航、无站点试验远程登记平台、临床试验协调、电子健康记录数据 提取和研究集成、生物库收集和存储、广泛的湿实验室服务和数据分析。 翻译科学课程，由SRTI研究团队负责人创建和指导，将纳入伦理和 可重复的研究实践、临床研究设计、有效沟通、恩赐精神、临床的社会背景 以及翻译研究、高级分析和精确健康方法。有指导的体验式培训将 包括专业发展研讨会、跨学科团队合作、社区咨询委员会演讲、 学生指导、客座课程指导和SRTI在机构间合作和学术活动中的代表 论坛。拟议的K12计划的目标是：1)增加2个翻译科学培训领域-数据 科学与人口健康-发挥我们在基因组学、数字健康和社区参与方面的优势，利用 扩展教师专业知识、新设计的课程以及与halıcıoğlu数据科学研究所的教育联盟。 加州大学圣地亚哥分校和圣地亚哥州立大学公共卫生学院；2)促进多样性、公平和包容性(DEI) 在课程、研究和体验式培训方面，通过提名的K12学者Dei联络和SRTI的Dei进行协调 以及3)通过增加导师结构和增加对学者向独立过渡的支持 导师培训，新的职业发展活动，以及作为桥梁的斯克里普斯医生科学家研究员计划 为职业生涯早期的教员。计划的K12项目成果包括100%保留和毕业指定学者， 90%的毕业生仍在从事研究工作，学者招聘的多样性增加到50%的女性和20%的群体 在科学界的代表性不足，以及从K12毕业生过渡到新开发的内科科学家研究员轨道。

Project Summary/Abstract Scripps Research Translational Institute’s (SRTI’s) K12 Program aims to deliver and develop comprehensive translational science competencies and successful translational scientist characteristics that launch graduates into investigational careers within academic institutions, research institutes, biotechnology companies, community and public health programs, and priority-setting government agencies. Within Scripps Research, the largest private, non-profit biomedical research organization in the United States, and together with partners Scripps Health, Rady Children’s Institute of Genomic Medicine, and San Diego State University (SDSU), we will provide a unique and inspirational setting for early-career biomedical researchers applying our translational science methodology strengths in the design and conduct of cutting- edge translational research. Six K12 scholars, ranging in level from clinical fellows to junior faculty within 5 years of training completion, will be supported for 2-4 years of mentored career development tailored for each to discover an investigational niche and generate preliminary findings toward individual grant submission and research independence. We will emphasize research activities mentored by a cross-disciplinary advisor team, assisted by academic cores and trial support providing grant management, feasibility assessments, regulatory support, community engagement consultation, study navigation, remote enrollment platforms for site-less trials, clinical trial coordination, electronic health records data extraction and study integration, biorepository collection and storage, extensive wet lab services, and data analytics. Translational science coursework, created and directed by SRTI research team leaders, will incorporate ethical and reproducible research practices, clinical study design, effective communication, grantsmanship, social contexts of clinical and translational research, advanced analytics, and precision health methodologies. Mentored experiential training will include professional development seminars, transdisciplinary teamwork, community advisory board presentations, student mentorship, guest course instruction, and SRTI representation in inter-institutional collaborations and academic forums. Objectives for the proposed K12 Program are: 1) the addition of 2 translational science training domains – data science and population health – to our strengths of genomics, digital health, and community engagement, capitalizing on expanded faculty expertise, newly designed coursework, and educational alliances with Halıcıoğlu Data Science Institute at University of California San Diego and SDSU’s School of Public Health; 2) advancing diversity, equity, and inclusion (DEI) in curricula, research, and experiential training, coordinated through a nominated K12 Scholar DEI Liaison and SRTI’s DEI Director; and 3) increasing support for scholar transition to independence through added mentorship structure and mentor training, new professional development activities, and a Scripps Physician Scientist Fellows Program as a bridge for early career faculty. Intended K12 program outcomes include 100% retention and graduation of appointed scholars, 90% of graduates remaining in research careers, increased scholar recruit diversity to 50% women and 20% from groups underrepresented in science, and transition of a K12 graduate to a newly developed Physician Scientist Fellows track.