Eradication of clonally expanded CD4+ T cells

项目摘要 克隆性扩增是潜伏感染的CD4+T细胞在 对同源抗原的反应。人们认为，这一过程对 与HIV宿主的大小相关，因此破坏这一机制可能会产生 对潜伏感染细胞的数量产生巨大影响。我们观察到一个显著的下降 在一名精英抑制者中扩增的CD4+T细胞克隆数量 肺癌的化学放射治疗，我们假设我们可以在体外重述这一点 通过用同源抗原组合刺激CD4+T细胞诱导 增殖，以及化疗或抗增殖剂 选择性地杀死分裂中的抗原特异性的CD4+T细胞。如果成功，将分两步进行 个体接种同源抗原疫苗的过程和短期治疗 化疗或抗增殖药物可能是减少肿瘤大小的策略的一部分。 蓄水池的。

Project Summary Clonal expansion is a process where latently infected CD4+ T cells proliferate in response to their cognate antigen. It is thought that this process contributes significantly to the size of the HIV reservoir and therefore disrupting this mechanism could have a huge impact on the number of latently infected cells. We observed a significant decline in the number of expanded CD4+ T cell clones in an elite suppressor who received chemoradiation for lung cancer and we hypothesize that we can recapitulate this in vitro by stimulating CD4+ T cells with a combination of cognate antigen to induce proliferation, and either chemotherapeutic or antiproliferative agents that would selectively kill the dividing antigen-specific CD4+ T cells. If successful, a two-step process of vaccination of individuals with cognate antigen and short term treatment with chemotherapeutic or antiproliferative agents may be part of a strategy to reduce the size of the reservoir.