Investigating Mechanisms of Neurodegeneration

项目总结 疾病和损伤会导致神经系统认知和运动能力的灾难性丧失。预防 神经退行性变是维持神经元功能的关键。为了开发有效的治疗方法，我们首先需要一种 更好地理解决定神经系统是否 因受到各种侮辱而堕落。秀丽线虫是一个非常容易处理的模型，可以进行解剖 保守的分子和细胞机制。这项提议的目标是利用线虫 识别轴突退变调节机制的模型。为了实现这一目标，我将把我的发展 具备详细的遗传分析、激光切断术、成像、测序和生物信息学方面的技能。这件事的影响 该项目意义重大。除了在理解基本机制方面取得重大进展外， 它还将为未来的治疗方法提供信息，这些方法可以被操纵以保护 神经系统不会退化。

PROJECT SUMMARY Disease and injury cause a catastrophic loss of cognitive and motor abilities in the nervous system. Preventing neurodegeneration is critical to maintaining neuronal function. To develop effective treatments, we first need a greater understanding of the genetic and cellular mechanisms that determine whether the nervous system degenerates in response to various insults. Caenorhabditis elegans is a highly tractable model to dissect conserved molecular and cellular mechanisms. The goal of this proposal is to take advantage of the C. elegans model to identify regulatory mechanisms of axon degeneration. To reach this goal, I will apply my developing skills in detailed genetic analyses, laser axotomy, imaging, sequencing, and bioinformatics. The impact of this project is significant. In addition to providing a critical advance in understanding the fundamental mechanisms of neurodegeneration, it will also inform future therapeutic approaches that can be manipulated to protect the nervous system from degenerating.