Administrative Core

核心A--摘要/摘要 我们这项计划拨款的最终目的是为了更好地了解非典型肺炎的异质性发病机制。 AD以及载脂蛋白E(Apo)E亚型是如何影响它的，使用人体组织，与 在各种AD模型中的发现，使用蛋白质组学和我们最近开发的其他方法。在……里面 我们特别关注载脂蛋白E(ApoE)亚型在以下方面的不同作用：1)AD斑块和 血管淀粉样蛋白形成(项目1)；2)针对Aβ/apoE相互作用的治疗方法(项目 2)；3)针对异常构象的治疗性免疫调节的反应(项目3)。这个 行政核心(核心A)负责确保这项研究提案的成功。目标是： 目标1.为计划项目赠款提供行政结构和财政监督。 目标2.组织由项目和核心领导人组成的执行委员会(EC)的定期会议 和其他关键人员协助科学管理，促进整合和持续 研究目标方面的进展。 目标3.与生物信息学/统计/数据管理核心D协调，以确保最佳数据 对计划项目的利用和科学严谨性。 目标4.与外部咨询委员会和内部咨询委员会密切互动，并定期开展 两个人的会议。外部咨询委员会和内部咨询委员会将提供科学建议 并为所有研究项目提供指导。 目标5.向国家卫生研究院报告进展情况，并确保遵守国家卫生研究院公共获取政策。 目标6.促进AD及相关障碍的教育，促进P01科学家参与教育 给研究人员、临床医生和患者/护理人员。

CORE A- SUMMARY/ABSTRACT Our ultimate goal of this program grant is to gain a better understanding of the heterogeneous pathogenesis of AD and how it is influenced by apolipoprotein (apo) E isotypes, using human tissue, with correlations to findings in various AD models, using proteomic and other methods which we have recently developed. In particular we are focusing on the differential role apolipoprotein E (apoE) isoforms play in: 1) AD plaque and vessel amyloid development (Project 1); 2) therapeutic approaches that target the Aβ/apoE interaction (Project 2); 3) responses to therapeutic immunomodulation targeting abnormal conformation (Project 3). The Administrative Core (Core A) is charged with ensuring the success of this research proposal. The Aims are: Aim 1. Provide administrative structure and fiscal oversight for the program project grant. Aim 2. Organize regular meetings of the Executive Committee (EC) composed of Project and Core Leaders and other key personnel to assist in scientific administration and to facilitate integration and continuing progress on research aims. Aim 3. Coordinate with the bioinformatics/statistical/data management Core D to ensure optimal data utilization and scientific rigor for the Program Project. Aim 4. Interact closely with the External Advisory Committee and Internal Advisory Board, and conduct regular meetings of both. The External Advisory Committee and Internal Advisory Board will provide scientific advice and guidance for all research projects. Aim 5. Report progress to NIH and ensure compliance with the NIH Public Access policy. Aim 6. Promote education on AD and related disorders, and facilitate P01 scientists’ participation in education to researchers, clinicians and patients/caregivers.