ShEEP Request for Particle Matrix ZetaView

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Extracellular vesicle (EV) research is a fast-moving area of research. Biological nanoparticles such as EVs, exosomes, viruses, lipids are part of normal homeostasis and now we believe a major part of pathological conditions. The San Francisco VA was the first in the UCSF community to purchase a NanoSight nanoparticle tracking system, 8 years ago. The field has moved very quickly and the new Particle Matrix ZetaView, we believe has replaced the NanoSight technology. The ZetaView can rapidly characterize particles as to size, particle concentration and surface charge. It also has the advantage of characterizing particles by fluorescent labelling without any additives and with a very small sample. The ZetaView has 4 lasers to enable the user to use different dyes to discriminate different particles and allows the user to quantify colocalization ratios of biomarkers. This nanoparticle tracking analysis is rapid and user friendly. This basic characterization of EV particles is essential in any project to use EVs as biomarkers and treatments. This new machine will attract new users to the field of EVS and facilitate current users for their funded projects.