Impact of Parental Long Term Thermoneutral Ambient Temperature on Offspring Health

第一个目标是确定多代环境温度，特别是热中和温度如何调节父母的代谢健康，并随后规划下一代的代谢健康。假设是，长期暴露在中温环境温度会导致脂肪组织功能失调，损害父母的代谢健康，从而增加后代肥胖的易感性。来自试点研究的初步数据已经表明 温度居中的父母所生后代的增重能力和脂肪组织形态的变化。第二个目标是确定父母住房温度对子代脂肪组织炎症分布的影响，重点是了解父母温度暴露在 调节脂肪组织炎症的程序设计。据推测，子代脂肪组织中的炎症反应在脂肪细胞和基质血管部分之间会有所不同，这是基于父母的住房温度。初步数据显示，亲代环境温度的变化会导致子代脂肪组织中参与免疫反应的基因表达发生变化。通过追求这些特定的目标，我们的目标是更好地了解环境温度在 亲代阶段影响后代的代谢程序。这些发现有可能揭示新的机制和干预措施，以降低肥胖风险和相关的健康并发症，最终有助于改善高收入国家的公共卫生结果。

The first objective is to determine how multi-generational ambient temperature, specifically thermoneutral temperature, modulates the metabolic health of parents and subsequently programs the metabolic health of the next generation. The hypothesis is that prolonged exposure to thermoneutral ambient temperature will lead to dysfunctional adipose tissue and impair the metabolic health of parents, resulting in an increased predisposition to obesity in the offspring. Preliminary data from pilot studies have already shown significant changes in the weight gain ability and adipose tissue morphology of offspring born to thermoneutral temperature housed parents to that offspring born to cold temperature housed parents. The second objective aims to identify the impact of parental housing temperature on the inflammatory profile of offspring adipose tissue, with a focus on understanding the role of parental temperature exposure in modulating adipose tissue inflammation programming. It is hypothesized that the inflammatory response in offspring adipose tissue will differ between adipocytes and the stromal vascular fraction based on parental housing temperature. Preliminary data showed that changes in parental ambient temperature resulted in changes in the expression of genes involved in immune response in offspring adipose tissue. By pursuing these specific aims, we aim to gain a better understanding of how ambient temperature modulation during parental stages influences the metabolic programming of offspring. The findings have the potential to uncover new mechanisms and interventions to reduce the risk of obesity and associated health complications, ultimately contributing to improved public health outcomes in high-income countries.