PHARMACOKINETIC AND ORAL BIOAVAILABILITY STUDIES IN RATS

本任务指令的目的是确定合适的配方，用于大鼠早期药代动力学研究的潜在候选药物的管理，并表征大鼠体内抗癌化合物的血浆药代动力学（PK）和生物利用度。将提供测试剂的化学结构、分子量（MW）和其他可用性质，并应用于提供配方方法的指导（例如，ph调整、共溶剂）。将提供路线和剂量水平（mg/kg）目标。

The purpose of this task order is to identify suitable formulations for administration of potential drug candidates to rats for early pharmacokinetic studies and to characterize the plasma pharmacokinetics (PK) and bioavailability of anticancer compounds in rats. Chemical structures, molecular weight (MW), and other available properties of test agents will be provided and should be used to provide guidance on formulation approaches (e.g., pH-adjustment, co-solvents). Route and dose level (mg/kg) targets will be provided. There will be a base period and optional tasks included under this task order. The base period will provide for formulation optimization/solubility assessment and one (1) rat pharmacokinetic study with one (1) compound.