FY23. TO 11 - CTN-0145: STANDARD VERSUS HIGH DOSE ED-INITIATED BUPRENORPHINE INDUCTION. POP: 8/28/23 - 8/27/24.

由NIDA资助的国家药物滥用治疗临床试验网络（CTN）最初成立于1999年，旨在弥合研究与实践之间的差距，以改善物质使用障碍的治疗。CTN是医疗和专业治疗提供者，治疗研究人员，参与患者和NIDA可以合作开发，验证，改进和向患者提供新的物质使用障碍治疗方案的一种手段。这种伙伴关系使行为，药理学和综合行为/药理学治疗干预措施在严格的，多地点的临床试验，以确定在广泛的社区为基础的治疗环境和不同的患者人群的治疗效果。这种伙伴关系还有助于将研究成果转移给医生，临床医生，提供者和患者，支持NIDA的最终目标，即加强向与物质使用障碍作斗争的个人提供基于科学的治疗。隶属于CTN的临床研究者提出临床研究的想法，如果被选中，则使用CTN平台开发和实施研究。临床试验网络（CTN）是一个由赠款资助的节点、合同临床协调中心、合同数据和统计中心以及合同后勤支持中心组成的协作框架。自2005年以来，埃姆斯公司已签约为NIDA CTN的临床协调中心。该合同是NIH帮助结束成瘾长期（HEAL）计划的一部分，旨在加速科学解决国家阿片类药物公共卫生危机。NIH HEAL倡议支持整个NIH的研究，以改善阿片类药物滥用和成瘾的治疗，并制定能够为阿片类药物危机提供快速和持久解决方案的具体战略。

The National Drug Abuse Treatment Clinical Trials Network (CTN), funded by NIDA, was first established in 1999 to bridge the gap between research and practice to improve treatment of substance use disorders. The CTN is a means by which medical and specialty treatment providers, treatment researchers, participating patients, and NIDA can partner to cooperatively develop, validate, refine, and deliver new substance use disorder treatment options to patients. This partnership enables the conduct of behavioral, pharmacological, and integrated behavioral / pharmacological treatment interventions in rigorous, multi-site clinical trials to determine treatment effectiveness across a broad range of community-based treatment settings and diverse patient populations. This partnership also aids in the transfer of research results to physicians, clinicians, providers, and patients, supporting NIDA’s ultimate goal of enhancing the delivery of scientifically based treatments to individuals struggling with substance use disorder. Clinical investigators affiliated with the CTN propose ideas for clinical research studies and, if selected, the study is developed and conducted using the CTN platform. The Clinical Trials Network (CTN) is a collaborative framework of grant-funded nodes, a contracted Clinical Coordinating Center, a contracted Data and Statistics Center, and a contracted Logistics Support Center. Since 2005, the Emmes Company has been contracted as the Clinical Coordinating Center for the NIDA CTN. This contract is part of the NIH’s Helping to End Addiction Long-term (HEAL) Initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction and to develop concrete strategies capable of providing rapid and durable solutions to the opioid crisis.