GENERATION R METABOLOMICS STUDY

NIEHS试图利用代谢组学来描述妊娠期炎症的纵向途径，以检查化学暴露和儿童生长结果的模式和关联。R世代研究是一个独特的前瞻性妊娠队列，具有丰富的产前非持久性化学物质暴露和儿童长期随访的现有信息。在这项研究中，将收集和分析在妊娠早期（<18周妊娠）和中期（18-25周妊娠）以及分娩时（脐带血血浆）的血浆样本的靶向和非靶向代谢组学分析，这些参与者现有的产前化学暴露措施以及儿童随访至少到6岁。

NIEHS seeks to characterize longitudinal pathways of inflammation in pregnancy using metabolomics in order to examine patterns and associations with chemical exposures and childhood growth outcomes. The Generation R study is a unique prospective pregnancy cohort with rich existing information on prenatal non-persistent chemical exposures and long-term follow-up of children. Under this study, targeted and non-targeted metabolomics analysis of plasma samples will be collected and analyzed at early (<18 weeks gestation) and mid (18-25 weeks gestation) pregnancy as well as at delivery (cord blood plasma) among participants who have existing measures of prenatal chemical exposures as well as childhood follow-up to at least age 6.