BEHAVIORAL MEASURES OF BINOCULAR VISION

描述（来自摘要）：斜视是视觉障碍的主要原因。 儿童残疾，影响到3%至4%的儿童， 生命的前六年 斜视的发展后果可能 在敏感期内通过手术干预缓解 双眼视觉的发展。 然而，功能性双眼视觉， 非常容易受到异常的早期视觉体验的影响，而不是 正常的双眼视觉，大多数儿童斜视治疗 发展出一种异常的感觉双眼视觉（单视 综合征），其特征在于中央凹抑制和减少 立体视觉 虽然单固定的临床特征 综合症是众所周知的，但人们对许多基本性质知之甚少 婴儿手术后双眼视觉的变化。 广大 这项研究的目的是调查 由于婴儿时期的斜视引起的运动和感觉的融合。 一 猕猴模型，它证明了许多异常的， 双眼视觉通常与单视综合征有关， 开发并将用于一系列的心理物理调查， 功能性双眼视觉 具体来说，将进行调查 为了获得视差的精细和粗略控制的定量描述， 聚散度，双眼视觉期间抑制的区域和深度，以及 具有局部和全局立体视觉的立体深度知觉。 结果 这些调查应该导致对机制的理解 在视差聚散的不精确性的基础上， 抑制和降低立体视锐度的患者与单固定 综合征 更好地理解未能充分发挥 在婴儿期重新建立眼间对准时恢复， 反过来，建议治疗，以提高术后恢复， 斜视儿童的双眼视觉

DESCRIPTION (from the abstract): Strabismus is a major cause of visual disability in the young, affecting 3 to 4 percent of children within the first six years of life. The developmental consequences of strabismus may be mitigated by surgical intervention during the sensitive period for the development of binocular vision. Functional binocular vision is, however, extremely vulnerable to abnormal early visual experience and, rather than normal binocular vision, the majority of children treated for strabismus develop a form of abnormal sensory binocular vision (the monofixation syndrome) that is characterized by foveal suppression and reduced stereoacuity. Although the clinical characteristics of the monofixation syndrome are well- known, little is known about many fundamental properties of binocular vision following surgical eye alignment in infants. The broad objective of the proposed research is to investigate the alterations of motor and sensory fusion caused by a period of strabismus during infancy. A macaque monkey model, which demonstrates many of the abnormalities of binocular vision usually associated with the monofixation syndrome, has been developed and will be used for a series of psychophysical investigations of functional binocular vision. Specifically, investigations will be conducted to obtain quantitative descriptions of fine and coarse control of disparity vergence, the area and depth of suppression during binocular vision, and stereoscopic depth perception with local and global stereopsis. The results of these investigations should lead to an understanding of the mechanisms underlying the imprecision of disparity vergence, the phenomenon of clinical suppression and the reduced stereoacuity of patients with the monofixation syndrome. A better understanding of the mechanisms that fail to fully recover when interocular alignment is re-established during infancy should, in turn, suggest treatments to enhance the post- surgical recovery of binocular vision in strabismic children.