NEW JERSEY CFS CRC

针对RFA AI-94-20，纳特尔森博士和他的同事提议 继续进行CFS合作研究中心的研究。这个 该中心的中心主题和目标是利用CFS患者的亚群 根据生物和神经/精神异常进行分层以获得 对病因和治疗的洞察。 该中心的目的将是继续集成诊断 最先进的病毒学和免疫学研究人员通过 一群擅长生理评估的内科医生和科学家 以及擅长精神病学和认知评估的心理学家。这个 研究方法从病毒的遗传和细胞水平转移 再激活和细胞因子的产生，到器官水平的生理性 功能，并从系统层面对神经/心理进行评估 疾病类型，以及患者的健康状况。 在头3年的支持中，疾病中心的修改 控制和预防(CDC)标准被用来确定一组 发病突然且无精神疾病的重症CFS患者 谁表现出更多的认知障碍和更多的异常病毒或 慢性疲劳综合征患者的免疫学指标与渐进型和现发性的比较 精神病学诊断。这一富有成效的战略将扩大到包括 一组病情较轻的CFS患者允许比较 轻、重度CFS。 提出了未来5年的三管齐下战略。 中心的活动。首先，从迄今获得的数据中综合出的想法 将推动旨在了解异常或原因的新研究 对CFS的影响。第二级规定每年进行两次纵向测试，以 确定CFS中恢复的预测因素。第三层是干预 体能训练试验，以确定是否打破了不活动的循环 可使生理、认知、病毒/免疫损伤正常化 改善健康状况。这些高度协作的研究代表着整合 医学、心理学和生理学。一个核心单元将提供 为所有研究项目提供行政和数据分析服务。

In response to RFA AI-94-20, Dr. Natelson and colleagues propose to continue the study of the CFS Cooperative Research Center (CRC). The central theme and goal of the Center is to use subgroups of CFS patients stratified by biological and neuro/psychiatric abnormalities to gain insight into etiology and treatment. The purpose of the Center will be to continue integrating the diagnostic capabilities of state-of-the-art virology and immunology researchers with a group of physicians and scientists expert at physiological evaluation and psychologists expert at psychiatric and cognitive assessment. The study approach moves from the genetic and cellular level of viral reactivation and cytokine production, to the organ level of physiological function, and to the system level to evaluate the neuro/psychological illness pattern, and fitness status of the patient. In the first 3 years of support, modifications of the Center for Diseases Control and Prevention (CDC) criteria were used to identify a group of severely ill CFS patients with sudden onset and no psychiatric morbidity who showed more cognitive impairment and more abnormal viral or immunologic parameters than CFS patients with gradual onset or current psychiatric diagnosis. This fruitful strategy will be extended to include a group of less severely ill CFS patients to allow comparisons between mild and severe CFS. A three-pronged strategy has been proposed for the next 5 years of the Center's activities. First, ideas synthesized from data obtained to date will fuel new studies aimed at understanding the abnormalities or causes of CFS. The second tier provides for biannual longitudinal testing to identify predictors of recovery in CFS. The third tier is an intervention trial of fitness training to determine if breaking the cycle of inactivity can normalize physiologic, cognitive, viral/immunologic impairments and improve health. These highly collaborative studies represent integration of medicine, psychology and physiology. One Core Unit will provide administrative and data analytic services to all research projects.