New Cures from Old Medicines - Targeting abnormal metabolism in Alzheimer's Disease

DREAM研究于2019年9月16日开始。已经测试了20种药物降低阿尔茨海默病和相关痴呆（ADRD）风险的能力。这些药物通常用于治疗风湿性关节炎、哮喘、糖尿病、高血压和癫痫等疾病。通过基于细胞培养的平行验证实验和转基因AD小鼠模型的长期体内研究，一些药物测试的令人鼓舞的结果正在得到证实。这些研究还包括评估候选AD药物对APP/PS1小鼠海马突触可塑性受损的修复能力。

The DREAM study began on 9/16/2019. 20 drugs have been tested for their ability to lower the risk of Alzheimer's disease and related dementias (ADRD). These drugs are commonly used to treat conditions including rheumatoid arthritis, asthma, diabetes, hypertension and epilepsy. Encouraging results from several of the drugs tested are being confirmed through parallel validation experiments in cell culture-based assays and long-term in vivo studies in transgenic AD mouse models. These studies also include evaluation of candidate AD drugs for their ability to rescue impaired hippocampal synaptic plasticity in APP/PS1 mice.