Leveraging existing HIV differentiated service delivery models to screen and treat hypertension in Ugandan persons living with HIV for dual control

项目总结/摘要 拟议中的全球新兴领袖奖的总体目标是支持马丁·穆杜博士的研究 培训，发展成为艾滋病毒和高血压的独立实施科学调查员。穆杜医生 是乌干达坎帕拉传染病研究合作组织（IDRC）的研究科学家。他 建议进行一项实施科学研究，将HTN筛查和治疗纳入 以社区为基础、以病人为中心的艾滋病护理模式，称为“差别化服务提供”。 完成本申请中提出的学习将有助于他的培训目标：1）掌握 混合方法实施科学研究; 2）获得设计和分析准 实验研究;和3）发展领导技能，赠款和手稿写作，并指导初级 investigators.这项建议建立在他在艾滋病毒和高血压临床医学方面已经拥有的技能基础上， 观察性研究方法。他将利用跨学科的导师和顾问团队， 在他的研究领域的专业知识，成为一个富有成效的独立研究员。高血压几乎影响 乌干达三分之一的艾滋病毒感染者，其中很大一部分未得到诊断和治疗。世界卫生 组织HEARTS包是HTN管理的循证策略，我们建议 调整、整合和实施社区艾滋病毒差异化服务提供模式， 实施科学方法。这将形成高血压-艾滋病综合差异化服务提供 模型然后，我们将评估高血压-艾滋病毒综合治疗方案的实施情况和有效性。 艾滋病毒感染者高血压控制的差异化服务提供模式。如果实施，该项目将 生成证据，为将HTN管理整合到以患者为中心的社区提供指导 艾滋病护理模式在乌干达和其他地区。

PROJECT SUMMARY/ABSTRACT The overall goal of the proposed Emerging Global Leader Award is to support Dr. Martin Muddu’s research training to develop as an independent implementation science investigator in HIV and hypertension. Dr. Muddu is a research scientist at the Infectious Diseases Research Collaboration (IDRC) in Kampala, Uganda. He proposes to conduct an implementation science study to integrate HTN screening and treatment into community-based, patient-centered models of HIV care known as “differentiated service delivery.” Accomplishing the proposed study in this application will facilitate his training goals to: 1) gain mastery of mixed methods implementation science research; 2) acquire expertise in design and analysis of quasi- experimental studies; and 3) develop skills in leadership, grant and manuscript writing, and mentoring of junior investigators. This proposal builds on the skills he already has in HIV and hypertension clinical medicine and methods of observational studies. He will leverage an interdisciplinary team of mentors and advisors with expertise in his area of study to become a productive independent researcher. Hypertension affects nearly one-third of Ugandan PLHIV, a large proportion of whom are undiagnosed and untreated. The World Health Organization HEARTS package is an evidence-based strategy for HTN management, which we propose to adapt, integrate, and implement into community HIV differentiated service delivery models using rigorous implementation science methods. This will form the integrated hypertension-HIV differentiated service delivery model. We will then evaluate the implementation and effectiveness of the integrated hypertension-HIV differentiated service delivery model regarding hypertension control in PLHIV. If implemented, this project will generate evidence to inform guidelines for integration of HTN management into patient centered community models of HIV care in Uganda and beyond.