REGIONAL CEREBRAL BLOOD FLOW IN PROGRESSIVE DEMENTIA

这项研究的主要长期目标是提供一个 安全、无创、经济有效的神经生物学方法， 老年痴呆症的诊断和治疗 梗塞性痴呆和抑郁症。 目前，差异 阿尔茨海默病的诊断是推定的，昂贵的，时间 消费，而且经常不准确，唯一明确的 通过检查脑组织得出的诊断。 当前 项目的设计是确定是否 通过测量皮质局部脑血流量 133氚吸入技术可以作为诊断以及 预测方法 另一个目标是研究 动态皮质功能在进展过程中， 阿尔茨海默氏病，多发性梗塞性痴呆和抑郁症。 等 数据可能具有预后价值。 成功完成本 研究将增加一个成本效益，非侵入性神经生物学 工具连接到差速器诊断电池。 在这个最初的项目中，一组阿尔茨海默病患者， 多梗塞性痴呆、抑郁症和未受损的受试者将 在休息和记忆任务期间进行rCBF测量， 至少四次：初次，此后每年。 每名患者/受试者还将接受全面的 神经心理学测试组合和神经系统检查 每次测量的日期。 静息和活化 将分析rCBF以确定是否存在独特的血流 各自的疾病模式。 神经心理学测试 数据将与静息和激活流相关，以进一步 在每个过程中阐明大脑行为的关系 disorder. 本方案中研究的患者/受试者将 通过随后的研究项目， 在他们各自的疾病过程中， 尽可能通过尸检获得诊断。

The major long-term objective of this research is to provide a safe, noninvasive, cost-effective neurobiological method of identifying and distinguishing Alzheimer's Disease from multi- infarct dementia and depression. Currently, the differential diagnosis of Alzheimer's disease is presumptive, costly, time consuming, and frequently inaccurate with the only unequivocal diagnoses coming from examination of brain tissue. The current project is designed as the first step in determining whether the measurement of cortical regional cerebral blood flow via the 133Xe inhalation technique can serve as a diagnostic as well as a prognostic method. Another objective is to study the changes in dynamic cortical functioning during the progressive course of Alzheimer's disease, multi-infarct dementia and depression. Such data could be of prognostic value. Successful completion of this research would add a cost effective, noninvasive neurobiological tool to the differential diagnostic battery. In this initial project, groups of patients with Alzheimer's disease, multi-infarct dementia, depression and unimpaired subjects will undergo rCBF measurements during rest and memory tasks on a minimum of four occasions: initial, and annually thereafter. Each patient/subject will also undergo a comprehensive neuropsychological test battery and a neurological examination on the day of each of these measurements. Resting and activated rCBF will be analyzed to determine if there are unique blood flow patterns for the respective disorders. The neuropsychological test data will be correlated with resting and activated flow to further elucidate brain-behavior relationships during the course of each disorder. The patients/subjects studied in this protocol will continue to be followed, through subsequent research projects, throughout the course of their respective disorders with definitive diagnoses being obtained via autopsy whenever possible.