INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS

描述(改编自申请人的摘要)：无菌松动 仍然是全髋关节置换术的一个问题。以胶结合计 髋关节置换是一种机械诱导的松动，最常发生在髋关节 骨柄-骨水泥或骨水泥-骨界面。虽然人们普遍认为 在骨水泥-骨界面处需要坚固的骨，最理想的是 对于骨水泥型股骨假体，水泥-金属界面是有争议的。一个 提出了研究方案：1)具体机械 股骨柄-骨水泥和骨水泥-骨界面的条件 故障；2)接口故障导致机械故障的方式 骨水泥股骨髋关节假体的松动；以及3)使用 用来“优化”骨水泥粘接位置和程度的信息 降低植入物失败的风险。在这里，“绑定”被用来描述任何 增强的杆-水泥界面(机械粗糙或预涂PMMA)； 与光滑的非粘合界面相比。这就是我们的假设 杆-水泥界面的粘结方式和程度的功 影响植入物的整体失败(松动)。它更远了 假设某些“最佳”配置，由以下区域组成 杆是粘合的，而杆未粘合的区域将导致 显著提高了植入物的长期性能。

DESCRIPTION (Adapted from the Applicant's Abstract): Aseptic loosening continues to be a problem with total hip replacements. In cemented total hip replacement, mechanically induced loosening most often initiates at the stem-cement or cement-bone interface. And while it is widely accepted that a strong bone is desirable at the cement-bone interface, the optimal cement-metal interface is disputed for cemented femoral components. A research program is proposed to investigate: 1) the specific mechanical conditions under which the femoral stem-cement and cement-bone interfaces fail; 2) the manner in which interface failure contributes to mechanical loosening of cemented femoral hip components; and 3) the use of this information to "optimize" the locations and extent of stem-cement bonding to reduce the risk of implant failure. Here, "bonding" is used to describe any enhanced stem-cement interface (mechanically roughened or PMMA precoated), as compared to a smooth unbonded interface. It is the hypothesis of this work that the manner and extent of bonding of the stem-cement interface affects the overall failure (loosening) of the implant. It is further hypothesized that some "optimum" configuration, consisting of regions where the stem is bonded, and regions where the stem is unbonded, will result in a significant increase in the long-term performance of the implant.