CONFERENCE: ANTIGEN AND CLONE-SPECIFIC IMMUNOREGULATION

在正常的动态平衡情况下，免疫系统会自行调节 敏感度极高的活动。然而，紊乱的免疫反应 引发并延续了大量严重的病理性疾病 疾病，从淋巴细胞性肿瘤到自身免疫性疾病。在……里面 与正常免疫的高效、克隆特异性方式形成对比 系统自我调节，处理这些问题的标准方法 免疫病理状态使用免疫抑制试剂 完全消融免疫反应。鉴于这种方法一直是 自身免疫性疾病或移植物的特殊情况下的巨大好处 拒绝，它的适用性受到非常真实的危险的限制 削弱了维持健康所需的免疫系统 个人。最近，基于对 基础免疫学，研究人员使用了各种各样的方法 开发的模型系统，甚至是患者应用程序，都利用 成功地导致调制的试剂和/或方法 以抗原特异性和/或克隆特异性方式的免疫反应。在……里面 从诱导抗原特异性T细胞耐受到诱导 在体外产生体内特异性抗肿瘤T细胞反应， 目前正在开发具有高度选择性的方法。这样的方法相当于 吸引人的是关于开发新的疾病治疗方法 免疫系统，因为它们有可能将反应留给 大多数独立的抗原都不受干扰。应该吸引参与者，并 代表广泛兴趣和专业知识的观众。它的 目的是将其工作与以下主题有关的个人聚集在一起 抗原和克隆对免疫功能的特异性调节，强调 关于所使用的实验方法和系统的多样性。它是 期望基础科学家、临床研究之间的互动 临床医生将推广新的定向治疗方法。 其发病机制包括不适当的免疫反应的疾病。

In the normal, homeostatic situation, the immune system regulates its own activity with exquisite sensitivity. However, a disordered immune response initiates and perpetuates a large number of serious pathological conditions, ranging from lymphocytic neoplasms to autoimmune disorders. In contrast to the efficient, clone-specific manner in which the normal immune system regulates itself, standard methods of treating these immunopathological states have employed immunosuppressive reagents to ablate the immune response altogether. Whereas this approach has been of tremendous benefit in particular instances of autoimmunes disease or graft rejection, its applicability is limited by the very real dangers of crippling an immune system required for the maintenance of the integrity of the individual. More recently, based upon an evolving understanding of basic immunology, investigators using a wide variety of approaches have developed model systems, and even patient applications, that utilize reagents and/or methodologies that successfully result in modulation of the immune response in an antigen-specific and/or clone-specific fashion. In situations ranging from the induction of antigen-specific T cell tolerance in vitro to the generation of specific anti-tumor T cell responses in vivo, highly selective approaches are being developed. Such approaches are quite attractive with respect to the development of new treatments of diseases of the immune system, since they have the potential of leaving responses to most independent antigens unperturbed. The should attract participants and an audience representing a wide range of interests and expertise. Its purpose is to bring together individuals whose work bears on the topic of antigen- and clone specific modulation of immune function, with an emphasis on the diversity of the experimental approaches and systems used. It is expected that the interaction between basic scientists, clinical researches and clinicians will promote new approaches to the directed therapy of disorders whose pathogenesis includes inappropriate immune responses.