Novel strategies for the treatment of alcohol dependance

拟议的项目旨在扩展我目前的项目，并通过解决成功治疗的三个障碍来改善酒精依赖的治疗。首先，将在一项随机对照试验中对酒精依赖和共病焦虑或抑郁进行一种新的、综合的、阶梯式护理治疗。其次，将描述睡眠障碍、复发、治疗保留和结果之间的关系。第三，研究抗渴望药物阿坎普罗酸和纳曲酮治疗的遗传预测因子。前两个目标将利用在悉尼三个地点招募的受试者，而第三个目标将涉及分析我目前项目中的血液样本和临床数据

The proposed project is designed to extend my current project and improve the treatment of alcohol dependence by addressing three barriers to successful treatment. Firstly, a novel, integrated, stepped-care treatment for alcohol dependence and comorbid anxiety or depression will be examined in a randomised controlled trial. Secondly, the relationship between sleep disturbances, relapse and treatment retention and outcomes will be characterised. Thirdly, genetic predictors to the treatment of the anti-craving medications, acamprosate and naltrexone will be investigated. The first two aims will utilise subjects recruited across three sites in Sydney while the third aim will involve analyses of blood samples and clinical data from my current project