Predoctoral Training in the Genetics of Development, Disease and Regeneration

项目摘要/摘要 基因组编辑和诱导多能干细胞技术的出现现在为创造 治疗和治愈许多发育疾病的疗法。然而，对基因的不完全了解 指导细胞分化和功能的调节机制是进展的重要障碍。 克服这一障碍将需要一支具有培训基础的员工队伍，该培训基础整合了 遗传学，对发育、细胞和分子机制的深入了解，以及应用的能力 干细胞生物学翻译潜力的基本概念。发育、疾病和遗传的遗传学 再生培训计划旨在培养跨学科知识和职业的广泛基础 使不同人群的学生能够将他们的培训应用于学习和治疗的发展 发育性疾病。为了实现这一目标，GDDR方案以五个培训基础为基础： 1)知识库，2)研究技能和创新技术，3)假设驱动的研究，4) 沟通技巧以及5)职业和职业发展。GDDR计划将创建一个独特的 通过将我们教员广泛和跨学科的研究兴趣与 将遗传原理和机制整合到发育和干细胞研究中的培训计划 生物学。30名资金雄厚、成就卓著的培训学院，来自10个基础科学和临床 各部门创造了一个高度协作和跨学科的环境。我们训练的广度 环境将为学员提供不同的论文培训实验室菜单，同时保持支持性 社区和促进GDDR计划与其他T32资助计划之间的有益互动 在科罗拉多大学安舒茨医学院。我们将充分利用这些互动来 开发涉及多个计划的课程和培训活动。因此，我们将扩大对 我们的学员将获得不同的知识、技术和职业机会，并扩大我们的影响 培训计划，使更多的学生和研究人员受益于CU AMC。以质量为本 和我们的学生队伍和培训学院的规模，我们建议每年支持6名实习生，这将 允许我们在建立一个互动的受训者小组时具有高度的选择性。我们的实习生招聘计划 旨在吸引来自不同背景的才华横溢的学生，从而为 为培训和成就做好准备。

PROJECT SUMMARY / ABSTRACT The advent of genome editing and induced pluripotent stem cell technologies now provide hope for creating therapies to treat and cure many developmental diseases. However, incomplete knowledge of the genetic regulatory mechanisms that guide cell differentiation and function stands as a significant barrier to progress. Overcoming this barrier will require a workforce with a training foundation that integrates a strong base in genetics, a deep knowledge of developmental, cellular and molecular mechanisms, and the ability to apply basic concepts to the translational potential of stem cell biology. The Genetics of Development, Disease, and Regeneration Training Program seeks to foster a broad foundation of interdisciplinary knowledge and career development that empowers a diverse population of students to apply their training to the study and treatment of developmental diseases. To achieve this goal, the GDDR Program is grounded in five training fundamentals: 1) knowledge base, 2) research skills and innovative technology, 3) hypothesis-driven research, 4) communication skills and 5) professional and career development. The GDDR Program will create a unique training environment by combining the broad and interdisciplinary research interests of our faculty with a training plan that integrates genetic principles and mechanisms into the study of development and stem cell biology. Thirty well-funded and accomplished Training Faculty drawn from 10 basic science and clinical departments create a highly collaborative and interdisciplinary environment. The breadth of our training environment will provide trainees with a diverse menu of labs for thesis training, while maintaining a supportive community and facilitating beneficial interactions between the GDDR Program and other T32-funded programs at the University of Colorado Anschutz Medical Campus. We will take full advantage of these interactions to develop courses and training activities that involve multiple programs. Thus we will broaden the exposure of our trainees to different knowledge, technologies, and career opportunities, and extend the impact of our training program to benefit a larger population of students and researchers at CU AMC. Based on the quality and size of our student pool and Training Faculty, we propose to support six trainees per year, which will permit us to be highly selective while building an interactive group of trainees. Our trainee recruitment plans are structured to attract highly talented students from diverse backgrounds, thereby contributing to a rich setting for training and accomplishment.