Cellular functions of Ran GTPase

工作业绩总结（2008年5月至今）该实验室现已具备进行基本生化和细胞生物学研究的设备。2. 一名博士后学生被录用（2009年4月到任），几名学生接受了面试，但到目前为止还没有做出进一步的决定。3. 动物水产设施的建设工作预计将于2009财年开始，预计将于2008年10月/ 11月完成。FLIM升级到蔡司710共聚焦显微镜的设计和所有组件已购买。该系统于2008年9月29日开始组装。5. 高通量筛选输入蛋白-输入蛋白相互作用的小分子抑制剂已在NCGC成功验证。6. 《酶学方法》的一章已经完成并正在出版，《生物物理杂志》正在审查一份研究手稿（合作）。另一篇受邀方法综述章节以及一篇研究手稿正在进行中。7. 会议：冷泉港会议口头报告（核功能动态组织，2008年9月17-21日），提交给美国细胞生物学学会年会上的海报摘要（旧金山，2008年12月）。8. 建立了四项新的国家和国际合作

Summary of accomplishments (Since May 2008) 1. The laboratory is now equipped to perform basic biochemical and cell biological work. 2. One postdoctoral student was hired (arrives April 2009), several interviewed but no further decisions made so far. 3. The work on the animal aquatic facility is expected to start with the new FY 09 and is supposed to be finalized in October/November 2008 4. The FLIM upgrade to Zeiss 710 confocal microscope was designed and all its components have been purchased. The assembly of the system started on September 29, 2008. 5. High throughput screen for small molecule inhibitors of importin alpha- importin beta interaction has been successfully validated at the NCGC. 6. A chapter for Methods in Enzymology was completed and is in press and a research manuscript (collaboration) is under review in Biophysical Journal. Another invited methods review chapter as well as a research manuscript are in progress. 7. Conferences: oral presentation at the Cold Spring Harbor Meeting (Dynamic Organization of Nuclear Function, Sept. 17-21, 2008), poster abstract submitted to the Annual Meeting of the American Society for Cell Biology (San Francisco, Dec. 2008). 8. Four new national and international collaborations were established