RAN-REGULATED IMPORTIN BETA CARGOS

RAN 监管的进口 Beta 货物

• 批准号: 8171445
• 负责人: Petr Kalab
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171445
• 关键词: Binding Proteins; Cell Nucleus; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Cytoplasm; Funding; Grant; Guanosine Triphosphate Phosphohydrolases; Institution; Interphase; Mediating; Mitotic; Mitotic spindle; Research; Research Personnel; Resources; Running; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ran GTPase is a key regulator of many cellular processes including the transport between nucleus and cytoplasm and of the mitotic spindle assembly. Many of such functions of Ran are mediated by RanGTP induced release of importin beta-binding protein cargos. We developed strategy to isolate Ran-regulated importin beta cargos quantitatively and in a highly purified form. The identification of the importin beta "transportome" by MuDPIT analysis will facilitate the discovery and understanding of the interphase and mitotic functions of Ran.

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