Project C: Transmission II Elimination

摘要 赞比亚致力于到2020年消除疟疾。2015年4月，赞比亚国家疟疾 控制中心（NMCC）发布了题为“从加速减轻负担转向疟疾”的战略计划， 消除：赞比亚2015-2020年战略”，目标是到2020年消除疟疾传播， 防止再次引入。这些目标将通过标准干预措施来实现， 管理、长效驱虫蚊帐、室内滞留喷洒、监测和 行为改变沟通以及加强战略，如大规模药物管理，并将 得到总统疟疾倡议、美国国际开发署、 比尔及梅林达·盖茨基金会和全球抗击艾滋病、结核病和疟疾基金。南部 该省是全国寄生虫流行率最低的省份，也是最有可能实现 先淘汰。根据南部和中部非洲国际环境监测和报告会议的主题， 关于控制和消除疟疾的障碍的研究问题，特别是对持续存在的 疟疾传播尽管目前采取了公共卫生干预措施， 调查在南部省实现、维持和记录消灭疟疾工作的障碍， 赞比亚.我们的目标涉及对实现、维持和记录疟疾至关重要的四个领域 消除：1）监测残留的传播疫源地; 2）对低水平传播的相对贡献 慢性感染者、无症状宿主和输入性疟疾; 3）次级病媒在 维持残余传播;和4）使用血清监测记录疟疾消除情况。

Abstract Zambia is committed to achieving malaria elimination by 2020. In April 2015, the Zambian National Malaria Control Centre (NMCC) released a strategic plan titled “Moving from accelerated burden reduction to malaria elimination: the Zambia 2015–2020 strategy” with the goals of eliminating malaria transmission by 2020 and preventing reintroduction. These goals are to be achieved through standard interventions such as case management, long-lasting insecticide-treated nets (LLINs), indoor residual spraying (IRS), surveillance and behavioral change communication as well as enhanced strategies such as mass drug administration, and will be supported in part by the President's Malaria Initiative, United States Agency for International Development, Bill & Melinda Gates Foundation and the Global Fund to Fight AIDS, Tuberculosis and Malaria. Southern Province has the lowest parasite prevalence in the country and is the province most likely to achieve elimination first. Consistent with the theme of the Southern and Central Africa ICEMR to address critical research questions on barriers to malaria control and elimination, specifically explanations for continued malaria transmission different epidemiological settings despite current public health interventions, we will investigate barriers to achieving, sustaining and documenting malaria elimination in Southern Province, Zambia. Our aims address four areas of critical importance to achieving, sustaining and documenting malaria elimination: 1) surveillance for residual foci of transmission; 2) relative contributions to low-level transmission of the chronically-infected, asymptomatic reservoir and imported malaria; 3) the role of secondary vectors in sustaining residual transmission; and 4) the use of serosurveillance to document malaria elimination.