Nucleosides, Nucleotides and Oligonucleotides GRC 2009

描述（由申请人提供）：本提案请求对核苷、核苷酸和寡核苷酸会议的部分支持，该会议是戈登研究会议系列的一部分，将于2009年7月5日至10日在Salve Regina大学（纽波特，RI）举行。会议的广泛和长期目标是增加我们对核苷，核苷酸和寡核苷酸化学的理解。这些药物作为诊断工具和治疗危及生命的疾病的药物的生物学意义将补充化学。这次会议的具体目标是召集9名讨论领导人主持9场会议。大会主席和副主席将监督整个会议。将有27位发言人将代表核苷，核苷酸和寡核苷酸的化学和生物学的关键领域。该计划将有一个主题演讲和八个会议，广泛讨论DNA复制，DNA修复，RNA转录，基因表达控制，核苷类似物作为治疗药物，其运输和代谢，以及核酸和核苷类似物的化学。此外，两次晚间海报会议将使所有与会者都能对这些主题作出贡献。这一应用的意义在于，戈登研究会议是唯一一个专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的平台。由于核苷类似物通过不同的机制起作用，对实体瘤和血液恶性肿瘤以及包括艾滋病在内的几种病毒性疾病的治疗非常有效，因此本次会议在其健康相关性方面具有重要意义。化学家和科学家之间的讨论将产生新的知识和新疗法的发展途径。同样，寡核苷酸已成为疾病预后和诊断的主要工具。真实的时间RT-PCR、PCR、反义寡核苷酸、核酶、RNAi、微小RNA和微阵列用于疾病诊断、预后和治疗中的若干步骤。我们专注于这些领域的会议将产生新的知识和合作。 公共卫生相关性：这一应用的意义在于，戈登研究会议是专注于“核苷，核苷酸和寡核苷酸”的化学家和生物学家聚集在一起的唯一平台。由于核苷类似物对治疗实体瘤和血液恶性肿瘤以及包括艾滋病在内的几种病毒性疾病非常有效，因此本次会议在其健康相关性方面具有重要意义。化学家和科学家之间的讨论将产生新的知识和新疗法的发展途径。同样，寡核苷酸已成为疾病预后和诊断的主要工具。真实的时间RT-PCR、PCR、反义寡核苷酸、核酶、RNAi、微小RNA和微阵列用于疾病诊断、预后和治疗中的若干步骤。我们专注于这些领域的会议将产生新的知识和合作。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from July 5 - 10, 2009. The broad and long term goal of the conference is to increase our understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides. The biological significance of these agents as tools for diagnosis and as drugs for treatment of life-threatening diseases will complement the chemistry. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. Chair and vice chairs of the conference will supervise the whole conference. There will be 27 speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides. The program will have a keynote address and eight sessions that broadly address current issues in DNA replication, DNA repair, RNA transcription, control of gene expression, nucleoside analogues as therapeutic agents, their transport and metabolism, and chemistry of nucleic acids and nucleoside analogues. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Because nucleoside analogues, acting by diverse mechanisms, are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS, this conference is highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Similarly, oligonucleotides have become major tools for prognosis and diagnosis of diseases. Real time RT-PCR, PCR, antisense oligonucleotides, ribozymes, RNAI, microRNAs and microarrays are used at several steps in disease diagnosis, prognosis, and treatment. Our conference focusing on these areas will generate new knowledge and collaborations. Public Health Relevance: The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on 'nucleosides, nucleotides, and oligonucleotides' come together. Because nucleoside analogues are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS, this conference is highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Similarly, oligonucleotides have become major tools for prognosis and diagnosis of diseases. Real time RT- PCR, PCR, antisense oligonucleotides, ribozymes, RNAI, microRNAs and microarrays are used at several steps in disease diagnosis, prognosis, and treatment. Our conference focusing on these areas will generate new knowledge and collaborations.