Benzene 2009: Health Effects and Mechanisms of Bone Marrow Toxicity. Implications

描述（由申请人提供） 本申请要求国家环境健康科学研究所（NIEHS）为将于2009年9月7日至11日在德国慕尼黑技术大学举行的题为"苯2009：健康影响、毒性机制、对t-AML的影响和行动模式框架的应用“的国际研讨会提供部分支持。自成立以来，NIEHS一直关注苯，因为它的职业和环境毒性。本次研讨会将致力于讨论苯诱导骨髓损伤机制的新发现。 苯是一种骨髓毒素和致癌物（白血病），尽管欧洲和美国的高度发达国家试图控制苯的暴露，但中国和亚洲其他地区的苯暴露仍然过量。已邀请报告最近关于苯引起的骨髓损害的流行病学研究。 研究人员将探讨苯相关骨髓病理生理学的进展，白血病发生的机制;苯诱导的白血病和抗癌治疗相关白血病之间的相似性;苯对骨髓分子生物学影响的最新研究;苯暴露;生物标志物，如染色体损伤;和风险评估。 他们将利用行动模式框架来评估苯的最新数据，并提出填补数据空白的建议，以加强风险评估进程。 将举行一次小组讨论会，讨论会上提出的问题，并将特别注意现行职业标准是否足以保护工人的问题。 已邀请了13个国家的发言者，并正在作出特别安排，让不发达国家的学生参加。会议记录将作为《化学-生物相互作用》的特刊出版。研讨会将探讨与苯有关的骨髓病理生理学、白血病发生机制、苯引起骨髓损伤的流行病学、苯对骨髓分子生物学影响的最新研究、苯暴露与生物标志物和风险评估等方面的最新进展。NIEHS的主要兴趣是苯暴露的环境影响和苯毒性的基本机制，以及如何在苯风险评估中利用这些数据。 许多讨论将直接涉及NIEHS的利益。

DESCRIPTION (provided by applicant) This application requests partial support from the National Institute for Environmental Health Sciences (NIEHS) for an international symposium entitled BENZENE 2009: Health effects, Mechanisms of Toxicity, Implications for t-AML and Application of the Mode of Action Framework, which will be held at the Technical University of Munich, Germany, September 7-11, 2009. Since its inception the NIEHS has been concerned with benzene because of both its occupational and its environmental toxicity. This symposium will devote its discussion to new findings on the mechanism of benzene-induced bone marrow damage. Benzene is a bone marrow toxin and carcinogen (leukemia) and despite attempts to control exposure in more highly developed countries in Europe and in the US, excessive benzene exposure persists in China and other areas of Asia. Reports have been invited on recent epidemiological studies of benzene-induced bone marrow damage. The investigators will explore advances in benzene-related bone marrow patho-physiology, mechanisms of leukemogenesis; the similarities between benzene-induced leukemia and anticancer treatment related leukemia; recent studies on the effects of benzene on the molecular biology of the bone marrow; benzene exposure; biomarkers such as chromosome damage; and risk assessment. They will make use of the Mode of Action framework when evaluating recent data on benzene and suggest data gaps which when filled will enhance the process of risk assessment. A panel discussion will deal with the issues raised at the meeting and special attention will be paid to the question of the adequacy of current occupational standards to protect workers. Speakers from 13 countries have been invited and special arrangements are being made to bring students from underdeveloped countries to participate. The proceedings will be published as a special issue of Chemico-Biological Interactions. The Symposium will explore recent advances in benzene-related bone marrow patho-physiology, mechanisms of leukemogenesis, epidemiology of benzene-induced bone marrow damage, recent studies on the effects of benzene on the molecular biology of the bone marrow, benzene exposure and biomarkers and risk assessment. The primary interests of NIEHS is in the environmental impacts of exposure to benzene and in fundamental mechanisms of benzene toxicity and how these data can be utilized in benzene risk assessment. Much of the discussion will relate directly to interests of the NIEHS.