Identification of autoantigens presented by specific HLA class I alleles in aplastic anemia
Identification of autoantigens presented by specific HLA class I alleles in aplastic anemia
批准号:
19H03686
负责人:
NAKAO Shinji
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2019
资助国家:
日本
项目状态:
已结题
起止时间:
2019-04-01 至 2022-03-31
中文摘要
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英文摘要
期刊论文(8)
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Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia
获得性再生障碍性贫血患者中,缺乏 HLA 的造血干祖细胞与缺乏 GPI 锚定蛋白的造血干祖细胞在层次阶段和对免疫攻击的敏感性方面有所不同
DOI:
10.1038/s41375-021-01202-8
发表时间:
2021
期刊:
Leukemia
影响因子:
11.4
作者:
[Yoroidaka T, Hosokawa K, Imi T, Mizumaki H, Katagiri T, Ishiyama K, Yamazaki H, Azuma F, Nanya Y, Ogawa S, Nakao S]
通讯作者:
Nakao S
A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia
白细胞中外显子 1 的常见 HLA 等位基因突变定义了导致获得性再生障碍性贫血自身抗原呈递的 I 类等位基因
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S, Hiroki Mizumaki]
通讯作者:
Hiroki Mizumaki
Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia
获得性再生障碍性贫血中 HLA-B4002 和 B5401 呈递的抗原特异性 T 细胞受体的鉴定
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S, Hiroki Mizumaki, Kohei Hosokawa]
通讯作者:
Kohei Hosokawa
DOI:
10.3324/haematol.2020.247809
发表时间:
2021-06-01
期刊:
Haematologica
影响因子:
10.1
作者:
[Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Anh Thi Nguyen M, Cao Tran D, Ibrahim Yousef Elbadry M, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S]
通讯作者:
Nakao S
Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15
携带 HLA-DR15 的环孢素依赖性再生障碍性贫血患者的造血干祖细胞频繁出现 HLA-DR 丢失
DOI:
10.1038/s41375-022-01549-6
发表时间:
2022
期刊:
Leukemia
影响因子:
11.4
作者:
[Tsuji Noriaki, Hosokawa Kohei, Urushihara Ryota, Tanabe Mikoto, Katagiri Takamasa, Ozawa Tatsuhiko, Takamatsu Hiroyuki, Ishiyama Ken, Yamazaki Hirohito, Kishi Hiroyuki, Ogawa Seishi, Nakao Shinji]
通讯作者:
Nakao Shinji
共 6 条
Identification of cytokines responsible for the development of immune-mediated bone marrow failure using gene expression analyses of patients with aplastic anemia
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批准号:25670448
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2013
-
负责人:NAKAO Shinji
-
依托单位:
Identification of myelosuppressive cytokines taking advantage of genomic abnormalities of leukocytes in patients with aplastic anemia
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批准号:24390243
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
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财政年份:2012
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负责人:NAKAO Shinji
-
依托单位:
Identification of auto-antigens in acquired aplastic anemia associated with clonal hematopoiesis by hematopoietic stem cells with uniparental disomy of chromosome 6p
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批准号:23659486
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:NAKAO Shinji
-
依托单位:
Identification of auto-antigens which trigger the development of immune-mediated bone marrow failure
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批准号:21390291
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
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财政年份:2009
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负责人:NAKAO Shinji
-
依托单位:
Identification of novel auto-antibodies and corresponding antigens in patients with aplastic anemia using CLIP replacement Ii chain library
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批准号:19390260
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2007
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负责人:NAKAO Shinji
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依托单位:
Analysis of mechanisms responsible for clonal expansion of PNH-type hematopoietic stem cells mediated by autoreactive T cells in patients with bone marrow failure
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批准号:17390275
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:2005
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负责人:NAKAO Shinji
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依托单位:
Analysis of autoantigens in aplastic anemia : identification of an epitope recognized by CD4^+ T cells specific to hematopoietic progenitor cells
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批准号:15390298
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.85万
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财政年份:2003
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负责人:NAKAO Shinji
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依托单位:
Analysis of autoantigens in immune-mediated aplastic anemia-identification of an epitope of a CD4^+ T-cell clone
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批准号:13470202
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.59万
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财政年份:2001
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负责人:NAKAO Shinji
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依托单位:
Identification of autoantigens in autoimmune aplastic anemia
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批准号:11670987
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:1999
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负责人:NAKAO Shinji
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依托单位:
Analysis of heat shock protein 70 as a causal molecule of aplastic anemia
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批准号:09671103
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1997
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负责人:NAKAO Shinji
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依托单位:
Isolation of T-cell clones cytotoxic agcirst nemotopoietic progenitor cells from a patienl with aplastic aremia
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批准号:06671080
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1994
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负责人:NAKAO Shinji
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依托单位:
海外基金