Identification of autoantigens presented by specific HLA class I alleles in aplastic anemia

再生障碍性贫血中特定 HLA I 类等位基因呈现的自身抗原的鉴定

• 批准号: 19H03686
• 负责人: NAKAO Shinji
• 金额: $ 11.23万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03686/
• 关键词: 再生不良性貧血; 自己抗原; HLA-B*40:02; T細胞レセプター; 発作性夜間ヘモグロビン尿症; HLA-DR15; HLA; 細胞傷害性T細胞; モノクローナル抗体; T cell receptor (TCR）; TCRトランスフェクタント; 末梢血造血幹前駆細胞; シクロスポリン; T細胞レセプタートランスフェクタント; HLAクラスI欠失血球; T cell receptor; TCR transfectant

项目成果

Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia

获得性再生障碍性贫血患者中，缺乏 HLA 的造血干祖细胞与缺乏 GPI 锚定蛋白的造血干祖细胞在层次阶段和对免疫攻击的敏感性方面有所不同

• DOI: 10.1038/s41375-021-01202-8
• 发表时间: 2021
• 期刊: Leukemia
• 影响因子: 11.4
• 作者: Yoroidaka T;Hosokawa K;Imi T;Mizumaki H;Katagiri T;Ishiyama K;Yamazaki H;Azuma F;Nanya Y;Ogawa S;Nakao S
• 通讯作者: Nakao S

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

白细胞中外显子 1 的常见 HLA 等位基因突变定义了导致获得性再生障碍性贫血自身抗原呈递的 I 类等位基因

• 发表时间: 2019
• 作者: Hosokawa K;Mizumaki H;Yoroidaka T;Maruyama H;Imi T;Tsuji N;Urushihara R;Tanabe M;Zaimoku Y;Nguyen MAT;Tran DC;Ishiyama K;Yamazaki H;Katagiri T;Takamatsu H;Hosomichi K;Tajima A;Azuma F;Ogawa S;Nakao S;Hiroki Mizumaki
• 通讯作者: Hiroki Mizumaki

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

获得性再生障碍性贫血中 HLA-B4002 和 B5401 呈递的抗原特异性 T 细胞受体的鉴定

• 发表时间: 2019
• 作者: Hosokawa K;Mizumaki H;Yoroidaka T;Maruyama H;Imi T;Tsuji N;Urushihara R;Tanabe M;Zaimoku Y;Nguyen MAT;Tran DC;Ishiyama K;Yamazaki H;Katagiri T;Takamatsu H;Hosomichi K;Tajima A;Azuma F;Ogawa S;Nakao S;Hiroki Mizumaki;Kohei Hosokawa
• 通讯作者: Kohei Hosokawa

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.

• DOI: 10.3324/haematol.2020.247809
• 发表时间: 2021-06-01
• 期刊: Haematologica
• 影响因子: 10.1
• 作者: Mizumaki H;Hosomichi K;Hosokawa K;Yoroidaka T;Imi T;Zaimoku Y;Katagiri T;Anh Thi Nguyen M;Cao Tran D;Ibrahim Yousef Elbadry M;Chonabayashi K;Yoshida Y;Takamatsu H;Ozawa T;Azuma F;Kishi H;Fujii Y;Ogawa S;Tajima A;Nakao S
• 通讯作者: Nakao S

Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15

携带 HLA-DR15 的环孢素依赖性再生障碍性贫血患者的造血干祖细胞频繁出现 HLA-DR 丢失

• DOI: 10.1038/s41375-022-01549-6
• 发表时间: 2022
• 期刊: Leukemia
• 影响因子: 11.4
• 作者: Tsuji Noriaki;Hosokawa Kohei;Urushihara Ryota;Tanabe Mikoto;Katagiri Takamasa;Ozawa Tatsuhiko;Takamatsu Hiroyuki;Ishiyama Ken;Yamazaki Hirohito;Kishi Hiroyuki;Ogawa Seishi;Nakao Shinji
• 通讯作者: Nakao Shinji