2009 Plant Metabolic Engineering Gordon Research Conference

描述(申请人提供)：已确认超过200,000个来自植物的单个化学实体或天然产品。鉴于手性中心的多样性，通过修饰取代基进行精制，以及这些化合物在植物和环境之间发挥的重要作用，植物天然产物在人类使用的大约三分之二的药物的设计和开发中发挥了很好的作用。后基因组时代现在为操纵植物化学提供了新的机会，这将进一步影响全球粮食供应的水平和营养含量，并导致新的药物和治疗化合物的新生物来源。为了提供一个多学科合作的发展环境，以揭开植物天然产物生物合成的复杂性和代谢网络的动力学，并促进植物代谢工程的基础和应用研究，以支持药物开发活动，我们请求支持将于2009年7月11日至17日在新罕布夏州沃特维尔山谷会议中心举行的2009年戈登研究会议(GRC)和植物代谢工程联合研究生研究研讨会(GRS)。与这一新系列会议的前两次会议类似，我们预计演讲者和参与者的数量将达到175人以上，来自美国和海外的所有职业水平的代表，以及来自学术界、工业、私人机构和联邦实验室的机构。协调一致的努力将继续鼓励妇女、残疾人和来自代表性不足群体的科学家参与。与2007年第一次一样，我们还将在GRC之前举办一次研究生研究研讨会(GRS)。我们的第一个GRS‘为初级科学家(博士生和博士后研究员)提供了一个独特的场所，让他们在直接同行的环境中展示他们的研究成果，学习如何在不同的受众中发展新的研究想法和概念，并帮助建立一个更具活力和互动性的科学社区，因为GRS的参与者也完全融入了更大的GRC会议。2009年全球资源报告将以“圆桌讨论”为中心，为与会者提供公开讨论与外地有关的一般问题的机会，从而使与会者有机会确定一个实地、一个社区和一个会议场所的所有权。GRS的所有与会者都将留在GRC，进一步加强这次会议的教育部分。 公共卫生相关性：项目描述植物代谢工程中的GRC为发展多学科合作和互动提供了一个环境，这些合作和互动需要揭开植物新陈代谢的动态复杂性，目的是操纵途径，以实现改变对人类健康、食物营养、能量生产和植物农艺生产具有重要意义的代谢物水平的目标。

DESCRIPTION (provided by applicant): More than 200,000 individual chemical entities or Natural Products from plants have been identified. Given the multiplicity of chiral centers, elaboration with modifying substituents and the important roles these compounds mediate between plants and the environment, plant natural products have served well in the design and development of approximately two-thirds of all the drugs used by mankind. The post-genomic era now presents new opportunities for manipulating plant chemistry that will further impact the level and nutritional content of the global food supply and lead to new biological sources of novel drugs and therapeutic compounds. To provide a setting for the development of the multidisciplinary collaborations needed to unravel the complexity of plant natural product biosynthesis and the dynamics of metabolic networks, and to advance basic and applied research in plant metabolic engineering in support of drug development activities, we are requesting support for the 2009 Gordon Research Conference (GRC) and joint Graduate Research Seminar (GRS) on Plant Metabolic Engineering to be held July 11-17, 2009 at the Waterville Valley conference center in New Hampshire. Similar to the first 2 meetings of this new conference series, we expect the number of speakers and participants to reach upwards of 175 persons from the US and abroad, at all career levels, and representing institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will continue to encourage the participation of women, persons with disabilities, and scientists from underrepresented groups. As was done for the first time in 2007, we will also host a Graduate Research Seminar (GRS) immediately prior to the GRC. Our first GRS' provided a unique venue for junior scientists (Ph.D. students and postdoctoral fellows) to present their research results in a setting of their direct peers, to learn how to evolve new research ideas and notions amongst a diverse audience, and helped to build a much more dynamic and interactive scientific community because the GRS participants were fully integrated into the larger GRC meeting as well. The 2009 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, thus providing the participants with an opportunity to establish ownership of a field, a community and a meeting venue. All participants to the GRS are expected to stay for the GRC, further enhancing the educational component of this conference. Public Health Relevance: Project Narrative the GRC in Plant Metabolic Engineering provides a setting for developing the multidisciplinary collaborations and interactions needed to unravel the dynamic complexity of plant metabolism with the purpose of manipulating pathways towards the goal of altering the levels of metabolites with importance to human health, food nutrition, energy production and agronomic production of plants.