A Disposable Amperometric Lithium Ion-selective Electrode for Home Testing

摘要 与锂的使用相关的治疗范围很窄，这意味着 需要对患者进行常规监测，以维持适当的锂水平。海流 监测方法不适用于患者在家中使用。这将转换为 为患者提供可靠的家庭检测工具以获取锂的需求日益增加 离子水平，以便他们可以方便有效地监测和管理他们的护理。测试 由于钠的干扰，血液中锂离子的浓度极具挑战性 离子。该研究计划将克服这一问题，并生产出一种用于 通过应用三个协调策略进行锂测试。战略1是开发 安培型离子选择电极，并使用施加的电位来调节选择性。 策略二是开发对钠离子具有高选择性的14-冠-4衍生物。 策略3是在一次测试中同时测量锂离子和钠离子浓度。 并用钠测量来修正锂的浓度。一项创新性研究 将这些策略集成到一次性一次性电化学测试条中的计划是 描述，包括测量概念、方法发展、离子载体的选择和 合成、电极设计和制造协议。 项目说明： 这项研究计划将生产一种基于安培离子选择电极的设备，用于 家庭血锂检测。

Summary There is a narrow therapeutic range associated with the use of lithium which translates to the need for routine patient monitoring to maintain the proper levels of lithium. The current monitoring methods are not amenable to home use by a patient. This translates to an increasing need to provide patients with a reliable home-based testing tool for obtaining lithium ion levels so that they can conveniently and effectively monitor and manage their care. Testing lithium ion concentration in blood is extremely challenging due to the interference from sodium ions. This research program will overcome this problem and produce a prototypical device for lithium testing through the application of three coordinated strategies. Strategy 1 is to develop amperometry-type ion-selective electrodes and use the applied potentials to tune the selectivity. Strategy 2 is to develop 14-crown-4 derivatives with a high selectivity against sodium ions. Strategy 3 is to simultaneously measure lithium and sodium ion concentrations in a single test and correct the lithium concentration with the sodium measurement. An innovative research plan for integrating these strategies into a disposable single-use electrochemical test strip is deschbed, including measurement concept, method development, ionophore selection and synthesis, electrode design and fabrication protocols. Project Narrative: This research program will produce an amperometric ion-selective electrode based device for home-based blood lithium testing.