Brain-activity during sedation predicting post-sedation explicit-memory

描述（由申请人提供）：本项目将研究脑电活动的措施，可能能够表明是否长期记忆正在发生，在轻度镇静。我们的目标是开发一种在手术室中使用的大脑监测器，以确定患者的麻醉水平是否变得太轻，这样患者就可以体验到疼痛，并了解手术室中发生的事情，并记住经验。这样的事件是罕见的，但创伤。目前还没有一种大脑分析系统能够准确地区分轻度麻醉中存在外显记忆的水平和外显记忆缺失的水平之间的界限。基本的科学目标是为进一步研究动物和人类的外显记忆机制提供工具。如果这一目标得以实现，它将为开发一种临床工具提供机会，用于分析、诊断或预测涉及记忆变化的医疗状况（目前的工具往往不足以解决这一问题）。该项目与健康有关，因为它解决了临床医学中的一个问题，如果成功，将为该问题提供解决方案。公共卫生相关性：该项目与公共卫生有关，因为它研究人类及其对麻醉剂镇静的反应，以找到一种方法来检测患者在手术中是否足够清醒，以记住经验。这在外科手术中是一种罕见的事件，但如果可能的话，应该通过本研究中开发的技术来预防。

DESCRIPTION (provided by applicant): This project will study electrical brain-activity measures that may be able to indicate whether or not long-term memory is occurring, under light sedation. The goal is to develop a brain-monitor to be used in the operating room to ascertain if a patient's level of anesthesia has become too light, such that the patient can experience pain, and understand what is occurring in the operating room, and remember the experience. Such an event is rare, but traumatic. No present brain-analysis system accurately distinguishes the boundary in light anesthesia, between that level in which there will be explicit-memory and that level in which explicit-memory is missing. The fundamental scientific goal is to provide a tool for further investigations of the mechanisms of explicit memory, in animals as well as humans. If the goal were achieved, it would offer the chance to develop a clinical tool for analysis, diagnosis, or prognosis of medical conditions involving changes in memory (for which present tools are often inadequate). The project is health-related in that it addresses a problem in clinical medicine, and will provide a solution to that problem, if successful. PUBLIC HEALTH RELEVANCE: This project is relevant to public health because it studies humans and their reactions to sedation under anesthetic agents, to find a way to detect whether, in an operation, the patient is alert enough to remember experiences. This is a rare event in surgery, but should be prevented, if possible, with the techniques that will be developed in this research.