Infection resistent coatings for mechanical circulatory support systems (MCSS)

描述（由申请方提供）：使用旁路移植术和植入式机械循环支持系统（MCSS）造成的高感染风险继续造成严重的临床并发症。在本I期提案中，Ension将开发并评估可应用于植入式器械、插管和传动系统的生物整合表面涂层的可行性。拟议的表面改性将包括一个表面层，其配制用于防止细菌粘附，以及一个移植的接近天然的胶原蛋白层，这将有利于正常的愈合反应，而不是形成一个厚的纤维囊，这可能会损害免疫功能。此外，所提出的工程化表面将适合于掺入抗菌剂，该抗菌剂将随时间以受控方式释放。拟定的I期SBIR的目标是开发和证明抗感染表面的可行性，目的是减少机械循环支持的感染相关并发症。公共卫生相关性：这项研究的产品是一种抗感染的表面涂层，可应用于任何穿过有感染风险的人体皮肤的医疗器械。这包括人工器官的表面和经皮组件、套管、瘘管和导管。

DESCRIPTION (provided by applicant): The high risk of infection posed by the use of paracorporeal and implanted mechanical circulatory support systems (MCSS) continues to create significant clinical complications. In this Phase I proposal, Ension will develop and assess the feasibility of a biointegrative surface coating that can be applied to implantable devices, cannulae, and drivelines. The proposed surface modification will consist of a surface layer formulated to prevent bacterial adhesion and a grafted near natural layer of collagen that will favor a normal healing response over the formation of a thick, fibrous capsule that can compromise immune function. In addition, the proposed engineered surface will be amenable to incorporating an antimicrobial that will release in a controlled manner over time. The goal of the proposed Phase I SBIR is to develop and demonstrate the feasibility of an infection resistant surface with the aim of reducing infection related complications of mechanical circulatory support. PUBLIC HEALTH RELEVANCE: The product of this research, an infection resistant surface coating, has application to any medical apparatus that passes through human skin at risk for infection. This includes the surfaces and transcutaneous component of artificial organs, cannula, fistula, and catheters.