Biobehavioral Studies of Cardiovascular Disease

描述（由申请人提供）： 这是PO 1 HL 040962“心血管疾病的生物行为研究”的更新申请。“该计划项目研究个体差异的心理生物学维度以及社会环境和营养暴露的变化，作为心脏病相关致病过程的潜在病因变量或标志物。我们提出了三个相关的研究项目，由三个核心单位的支持。研究人员代表心理学和精神病学，临床药理学，人类神经科学，分子遗传学，细胞生物学，流行病学和统计学。项目1旨在确定心血管疾病的社会心理和生活方式相关风险因素是否与情绪处理和食欲动机的关键神经结构反应性的个体差异相关。项目2将调查社会环境中与压力相关的特征（包括职业和家庭环境），跟踪个人真实的行为和生物反应，并阐明临床前血管疾病的途径。项目3将探讨通过观察和实验方法研究的与几种行为和生物风险因素-ω-3脂肪酸-潜在相关的机制。这些目标将在一个单一的、多组成部分的数据收集的范围内实现，这将既满足各个项目的具体目标，又为跨方法和跨分析层次的协同探索创造机会。研究样本将包括530名没有临床明显动脉粥样硬化疾病的中年人，研究方法将包括功能性神经成像、经历环境的生态瞬时评估、动态血压和神经内分泌评估、实验室临床评估、异质性人格和健康行为评估、血管成像和分子遗传学分析。这些项目由核心单位提供便利，这些单位提供集中的行政、数据管理和参与人应计服务;仪器支持和开发;以及一般生物统计和专门数据分析服务和咨询。

DESCRIPTION (provided by applicant): This is the renewal application for PO1 HL040962, "Biobehavioral Studies of Cardiovascular Disease." This Program Project studies psychobiological dimensions of individual differences and variation in socioenvironmental and nutritional exposures as potential etiological variables or markers of correlated pathogenic processes in heart disease. We propose three related research projects, supported by three Core Units. Investigators represent psychology and psychiatry, clinical pharmacology, human neuroscience, molecular genetics, cell biology, epidemiology, and statistics. Project 1 seeks to establish whether psychosocial and lifestyle-related risk factors for cardiovascular disease are associated with individual differences in the reactivity of key neural structures underlying emotional processing and appetitive motivation. Project 2 will investigate stress-related features of the social environment (in both occupational and home contexts), tracking individuals' behavioral and biological reactions in real time and elucidating pathways to preclinical vascular disease. Project 3 will address a mechanism of potential relevance to several behavioral and biological risk factors - omega-3 fatty acids - as studied by both observational and experimental methodologies. These objectives will be pursued in the context of a single, multi-component data collection that will both satisfy specific aims of the individual projects and create opportunities for synergistic exploration across methods and levels of analysis. The study sample will include 530 middle-aged adults without clinically apparent atherosclerotic disease, and study methods will encompass functional neuroimaging, ecological momentary assessment of experienced environments, ambulatory blood pressure and neuroendocrine assessments, laboratory clinical evaluations, heteromethod personality and health behavior assessments, vascular imaging, and molecular genetic analyses. These Projects are facilitated by Core Units providing centralized administrative, data management and participant accrual services; instrumentation support and development; and both general biostatistical and specialized data analytic services and consultation.