Biobehavioral Studies of Cardiovascular Disease

摘要 心血管疾病的生物行为研究(PO1-HL040962) 本计划项目(P01)继续应用重点是人脑基础的行为和 社会环境对中年成年人心血管疾病风险的影响。建议的项目有3个 在概念上是交叉链接的，并由3个核心单元支持。协作型调查人员代表 多学科，包括心理学，神经科学，生物物理学，医学，心理神经免疫学， 流行病学、机器学习、生物信息学和统计学。项目1旨在阐明功能和 预测临床前血管疾病多年进展的结构性脑表型和 功能障碍，重点是内脏控制的神经回路，协调自主神经，神经内分泌， 与压力和情绪相关的行为过程的血液动力学和免疫生理学。项目2的目标 为了确定这些内脏控制回路的功能特征是否缓和了 应激相关环境暴露对临床前血管疾病和功能障碍进展的影响 在日常生活中跟踪个体的行为和心血管生理以测试一种新的神经素质模型 心血管疾病风险。项目2还首次测试日常生活体力活动是否与日常生活相关联 应激生理学通过其影响神经回路进行内脏控制。项目3旨在扩展其他项目的功能 通过阐明神经和外周过程将体力活动与生理和 心血管疾病风险的心理生理标记物(包括日常生活影响和应激生理学) 实验干预方法论。这些P01目标在心血管行为医学中是独一无二的，并且 它们将在满足所有特定项目的多组成部分数据收集工作的背景下进行 目标。因此，P01将为人类的综合和翻译科学创造新的机会 心血管疾病风险的神经生物学，跨越多种方法和分析水平。帮助推进ITS 父领域，P01将生成和传播原创的和可扩展的公共领域资源和工具，以 通过全面的数据和软件共享以及 教育目标。这项研究的队列包括近900人，使人们能够准确地关注早期心血管疾病的病因 没有临床表现的CVD的中年成年人，研究方法将包括 神经成像、体验环境的生态瞬时评估、动态血流动力学 监测、自主神经、神经内分泌、免疫和血管评估、实验室临床评估、 不同方法的健康行为评估和动脉成像。本P01的三个核心单位提供 通过行政、数据管理和参与方应计服务实现协同作用和项目间协调； 测量和仪器支持；以及在前沿生物统计和数据密集型方面的指导 (机器学习)分析。因此，本申请是专题的延续，下一步-- P01是对心血管疾病的翻译神经生物学研究的世代延伸，于1988年启动。

ABSTRACT Biobehavioral Studies of Cardiovascular Disease (PO1-HL040962) This Program Project (P01) continuation application focuses on the human brain substrates of behavioral and socio-environmental influences on cardiovascular disease (CVD) risk in midlife adults. Proposed are 3 Projects that are conceptually cross-linked and supported by 3 Core Units. Collaborative investigators represent multiple disciplines, including psychology, neuroscience, biophysics, medicine, psychoneuroimmunology, epidemiology, machine learning, bioinformatics, and statistics. Project 1 aims to elucidate functional and structural brain phenotypes that predict the multiyear progression of preclinical vascular disease and dysfunction, with a focus on neural circuitries for visceral control that coordinate autonomic, neuroendocrine, hemodynamic, and immune physiology with stress- and emotion-related behavioral processes. Project 2 aims to establish whether functional characteristics of these visceral control circuits moderate the influences of stress-related environmental exposures on the progression of preclinical vascular disease and dysfunction, tracking individuals' behavior and cardiovascular physiology in daily life to test a novel neuro-diathesis model of CVD risk. Project 2 also tests for the first time whether daily life physical activity associates with daily life stress physiology through its effects neural circuits for visceral control. Project 3 aims extend those of the other Projects by elucidating the neural and peripheral processes linking physical activity with physiological and psychophysiological markers of CVD risk (including daily life affect and stress physiology) using an experimental intervention methodology. These P01 aims are unique in cardiovascular behavioral medicine, and they will be pursued in the context of multi-component data collection efforts that satisfy all project-specific aims. As a result, the P01 will create new opportunities for integrative and translational science on the human neurobiology of CVD risk that cuts across multiple methods and levels of analysis. Helping to advance its parent field, the P01 will generate and disseminate original and expansive public-domain resources and tools to the broader scientific and clinical communities through comprehensive data and software sharing and educational objectives. Enabling a precise focus on early CVD etiology, the study cohorts comprise nearly 900 midlife adults without clinically apparent CVD, and study methods will include novel combinations of neuroimaging, ecological momentary assessments of experienced environments, ambulatory hemodynamic monitoring, autonomic, neuroendocrine, immune, and vascular assessments, laboratory clinical evaluations, hetero-method health behavior assessments, and arterial imaging. The 3 Core Units of this P01 provide for synergy and inter-project coordination by administrative, data management and participant accrual services; measurement and instrumentation support; and direction in cutting-edge bio-statistical and data-intensive (machine learning) analyses. The present application thus represents a thematic continuation and next- generation extension of translational neurobiological research on CVD by this P01, which was initiated in 1988.