Ctrs for Medical Countermeasures Against Radiation

这一研究应用的广泛和长期目标侧重于快速生物剂量测定和减轻辐射损伤以及推进这一领域的教育。许多人认为，对美国最大的威胁是核扩散和核装置在美国本土爆炸的可能性。该中心补助金申请将解决医疗需求，将出现这样的事件发生时。每个项目都由一个国际知名的研究团队领导。许多主要研究人员对辐射损伤的正常组织反应的研究历史悠久。虽然一些项目PI不是辐射科学家，但该中心的组织结构是从辐射科学的各个方面汲取广泛的专业知识。辐射生物学，辐射肿瘤学和物理学领域的杰出教师是该中心的领导者和积极参与者。该组织提供了一个基础设施，使辐射科学领域以外的专家进入中心，以最大限度地提高他们成功开发与手头任务相关的治疗或诊断方法的可能性。这些研究人员联合起来，形成了一个全面的，包容性的，跨机构和跨学科的辐射医疗对策中心（CMCR）。总体主题是：1）用于快速筛选的新型生物剂量测定方法，2）减轻正常组织损伤，重点是：a.）免疫系统，B.）lung，c.）胃肠道和，d.）造血因此，广泛的科学的具体目标如下：目标1：开发诊断测试的快速和有效的生物剂量学的基础上，光刺激发光和DNA的阵列。这将通过支持方案1中的工作来实现。目标2：开发新型、安全、有效的减轻辐射损伤的药物或候选分子。这一目标将通过方案2和方案3的工作来实现。目标3：开发新型、安全和有效的药物或候选分子，用于增强辐射暴露后的免疫恢复。这将在方案4中完成。中心的所有核心将支持实现目标1、2和3的可交付成果的工作。同样重要的是这群调查人员的专业知识，他们致力于一项教育计划，在这个困难的领域培训年轻的调查人员。这些目标完全支持以下使命：在遵循NIH路线图的同时，识别和开发将减轻辐照暴露影响的可交付成果。

The broad and long term objectives of this research application focuses on rapid biodosimetry and mitigation of radiation injury as well as advancing education in this area. Many individuals believe that the single greatest threat to America is nuclear proliferation and the possibility of a nuclear device detonation on American soil. This center grant application will address the medical needs that would arise should such an event occur. Each program is led by a team of internationally renowned investigators. Many of the principal investigators have a long history of studies on normal tissue responses to radiation injury. While some project PIs are not radiation scientists, the organization of the Center is such that broad based expertise is drawn from all aspects of radiation sciences. Eminent faculty in the areas of radiation biology, radiation oncology and physics are leaders and active participants in this center. This organization provides an infrastructure that brings experts outside the field of radiation sciences into the center in a way that will maximize the likelihood that they will be successful in developing therapies or diagnostics pertinent to the tasks at hand. These investigators have united to form a comprehensive, inclusive, inter-institutional, and interdisciplinary Center for Medical Countermeasures against Radiation (CMCR). The overarching themes are those of: 1) Novel biodosimetry methods for rapid screening, 2) Mitigation of normal tissue injury with focus on: a.) the immune system, b.) lung, c.) gastrointestinal tract and, d.) hematopoiesis. Thus, the broad scientific specific aims are as follows: Aim 1: To develop diagnostic tests for rapid and effective biodosimetry based on optically stimulated luminescence and on DNA based arrays. This will be accomplished by support of work in Program 1. Aim 2: Development of novel, safe and effective drugs or candidate molecules for mitigation of radiation injury. This aim will be accomplished through work on Programs 2 and 3. Aim 3: Development of novel, safe and effective drugs or candidate molecules for enhancing immune recovery following exposure to radiation. This will be accomplished under Program 4. All the cores of the center will support the work to achieve the deliverables for Aim 1, 2 and 3. Equally important is the expertise of this group of investigators who are committed to an educational program to train young investigators in this difficult area. These aims fully support the mission of identifying and developing deliverables that will mitigate the effects of exposure to irradiation while following the NIH roadmap.