Development Influences of Sexual & Romantic Relationships on Adolescnt Male STI R

项目3的长期目标是描述 青年男子从青春期中后期到青年 成年具体目的是：（1）通过5项性行为指标描述青少年男性的感染模式， 传播的微生物（C.沙眼淋病奈瑟菌阴道毛滴虫 生殖支原体、溶脲脲原体生物型2）和非淋菌性尿道炎与 （2）描述青春期男性感染的获得、排菌、症状、体征、体征等特征 每种靶微生物的脓尿，使用事件相关的每隔一天样本， 描述与之相关的心理、人际、社会和行为现象 与青少年男性使用电子手机日记报告发生性事件的关系。通过 临床核心，我们将招募234名非洲裔美国人，拉丁美洲人和欧美年轻男子，年龄在14-17岁， 从性传播感染流行率高的社区招募。参与者将被随访长达57个月。在 与核心实验室一起，我们将每月检测一次尿液样本，并更频繁地 事件相关样本，PCR和细胞计数，以表征上述5种STI的自然史 和非淋菌性尿道炎每季度的音频计算机辅助自我面试（ACASI）将用于 描述STI获得的人口统计学、行为学、生物学和社会文化相关性， 顺序每天的手机日记将被用来描述心理，人际关系和行为 与特定性事件和性传播感染有关的现象。研究提出了三个 与科学、技术和创新有关的优先事项：（1）以青少年为重点，（2）不同生物体之间的相互作用， 包括新出现的病原体如M.生殖器和（3）提供关键的发展 流行病学和行为数据，为干预措施提供信息。

The long-term objective of Project 3 is to characterize the natural history and developmental epidemiology of sexually transmitted infections (STI) among young men from middle to late adolescence and into young adulthood. The,specific aims are: (1) To describe adolescent men's patterns of infection by 5 sexually transmitted organisms (C. trachomatis trachomatis. Neisseria gonorrhoeae. Trichomonas vaginalis. Mycoplasma genitalium, Ureaplasma urealyticum, biovar 2), and non-gonococcal urethritis as a function of time; (2) To describe adolescent men's patterns of infection acquisition, organism shedding, symptom development, and pyuria for each target organism using event-contingent every other day samples for 14 days; And (3) To describe the psychological, interpersonal, social and behavioral phenomena associated with occurrence of sexual events using electronic cell phone diary reports among adolescent men. Through the Clinical Core, we will recruit 234 African American, Latino and Euro-American young men, ages 14-17 at enrollment, from a community with high STI prevalence. Participants will be followed for up to 57 months. In conjunction with the Laboratory Core, we will test monthly surveillance urine samples and more frequent event-contingent samples with PCR and cell counts to characterize the natural history ofthe above 5 STI and NGU across adolescence. Quarterly audio computer assisted self interviews (ACASI) will be used to characterize demographic, behavioral, biological, and socio-cultural correlates of STI acquisition and sequence. Daily cell phone diaries will be used to describe the psychological, interpersonal, and behavioral phenomena associated with specific sexual events and STI. The proposed research addressed three priorities related to STI: (1) A focus on adolescents, (2) The interactions among different organisms, including emerging pathogens such as M. genitalium and (3) the provision of key developmental epidemiology and behavioral data to inform interventions.